Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies

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Title: Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies
Authors: Molina-Martín, Ainhoa | Piñero, David P. | Pérez Cambrodí, Rafael J.
Research Group/s: Grupo de Óptica y Percepción Visual (GOPV)
Center, Department or Service: Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía
Keywords: Microperimetry | Early detection | Ocular anomalies | Hydroxychloroquine
Knowledge Area: Óptica
Issue Date: 2015
Publisher: Hindawi Publishing Corporation
Citation: Journal of Ophthalmology, vol. 2015, Article ID 437271, 4 pages, 2015. doi:10.1155/2015/437271
Abstract: Purpose. To evaluate the usefulness of microperimetry in the early detection of the ocular anomalies associated with the use of hydroxychloroquine. Methods. Prospective comparative case series study comprising 14 healthy eyes of 7 patients (group A) and 14 eyes of 7 patients under treatment with hydroxychloroquine for the treatment of rheumatologic diseases and without fundoscopic or perimetric anomalies (group B). A comprehensive ophthalmological examination including microperimetry (MP) and spectraldomain optical coherence tomography was performed in both groups. Results. No significant differences were found in mean MP foveal sensitivity between groups (P = 0.18). However, mean MP overall sensitivity was significantly higher in group A (29.05 ± 0.57 dB versus group B, 26.05 ± 2.75 dB; P < 0.001). Significantly higher sensitivity values were obtained in group A in comparison to group B for the three eccentric loci evaluated (P < 0.001). Conclusion. Microperimetry seems to be a useful tool for the early detection of retinal damage in patients treated with hydroxychloroquine.
URI: http://hdl.handle.net/10045/45882
ISSN: 2090-004X (Print) | 2090-0058 (Online)
DOI: 10.1155/2015/437271
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2015 A. Molina-Martín et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Peer Review: si
Publisher version: http://dx.doi.org/10.1155/2015/437271
Appears in Collections:INV - GOPV - Artículos de Revistas
INV - GIOptom - Artículos de Revistas

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