NHC-Ligand Effectiveness in the Fluorine-Free Hiyama Reaction of Aryl Halides
Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10045/40222
Registro completo de metadatos
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor | Nuevos Materiales y Catalizadores (MATCAT) | es |
dc.contributor | Síntesis Asimétrica (SINTAS) | es |
dc.contributor.author | Peñafiel Andrés, Itziar | - |
dc.contributor.author | Pastor, Isidro M. | - |
dc.contributor.author | Yus, Miguel | - |
dc.contributor.other | Universidad de Alicante. Departamento de Química Orgánica | es |
dc.contributor.other | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica | es |
dc.date.accessioned | 2014-09-12T08:33:31Z | - |
dc.date.available | 2014-09-12T08:33:31Z | - |
dc.date.issued | 2013-03 | - |
dc.identifier.citation | European Journal of Organic Chemistry. 2013, 2013(8): 1479-1484. doi:10.1002/ejoc.201201066 | es |
dc.identifier.issn | 1434-193X (Print) | - |
dc.identifier.issn | 1099-0690 (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/40222 | - |
dc.description.abstract | 1-Benzyl-3-(2-hydroxy-2-phenylethyl)imidazolium chloride (5), which is a precursor of an N-heterocyclic carbene ligand, in combination with palladium acetate, has been employed as an effective catalyst for the fluorine-free Hiyama reaction. A systematic study of the catalytic mixture, by a 32 factorial design, has revealed that both the amount of palladium and the Pd/NHC precursor ratio are important factors for obtaining good yields of the coupling products, indicating an interaction between them. The best catalytic system involves mixing 0.1 mol-% palladium acetate in a 1:5 ratio (Pd/salt 5), which allows the effective coupling of a range of aryl bromides and chlorides with trimethoxy(phenyl)silane. The Hiyama reactions are carried out in NaOH solution (50 % H2O w/w), at 120 °C under microwave irradiation during 60 min. | es |
dc.description.sponsorship | Financial support from the Spanish Ministerio de Ciencia e Innovación (MICINN) (project numbers CTQ2007-65218, CTQ2011-24165), from Consolider Ingenio 2010 (CSD2007-00006), from the Generalitat Valenciana (PROMETEO/2009/0349), and from the Fondos Europeos para el Desarrollo Regional (FEDER) is acknowledged. I. P. thanks the MICINN for a predoctoral fellowship. | es |
dc.language | eng | es |
dc.publisher | Wiley-VCH Verlag GmbH & Co. KGaA | es |
dc.rights | © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | es |
dc.subject | Synthetic methods | es |
dc.subject | Homogeneous catalysis | es |
dc.subject | Palladium | es |
dc.subject | Nitrogen heterocycles | es |
dc.subject | Cross-coupling | es |
dc.subject | Carbene ligands | es |
dc.subject.other | Química Orgánica | es |
dc.title | NHC-Ligand Effectiveness in the Fluorine-Free Hiyama Reaction of Aryl Halides | es |
dc.type | info:eu-repo/semantics/article | es |
dc.peerreviewed | si | es |
dc.identifier.doi | 10.1002/ejoc.201201066 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1002/ejoc.201201066 | es |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | es |
Aparece en las colecciones: | INV - SINTAS - Artículos de Revistas INV - MATCAT - Artículos de Revistas INV - AMIC - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2013_Penafiel_etal_EurJOC_final.pdf | Versión final (acceso restringido) | 969,58 kB | Adobe PDF | Abrir Solicitar una copia |
Todos los documentos en RUA están protegidos por derechos de autor. Algunos derechos reservados.