Palladium(II) pincer complexes of α-amino acids: towards the synthesis of catalytically active artificial peptides

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Title: Palladium(II) pincer complexes of α-amino acids: towards the synthesis of catalytically active artificial peptides
Authors: Guillena, Gabriela | Rodríguez, Gema | Van Koten, Gerard
Research Group/s: Catálisis Estereoselectiva en Síntesis Orgánica (CESO)
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Keywords: Palladium | Pincer | Complexes | Aminoacids
Knowledge Area: Química Orgánica
Issue Date: 20-May-2002
Publisher: Pergamon
Citation: Tetrahedron Letters. 2002, 43(21): 3895-3898. doi:10.1016/S0040-4039(02)00656-1
Abstract: NCN palladium(II) complexes have been covalently attached to the N- and C-terminus of the dipeptide L-Phe-L-Va-OMe. Remarkably, the hydrolysis of the NCN-Pd(II) L-Val-OMe afforded the corresponding, palladated free amino acid without affecting the metal site. This deprotected amino acid could be coupled to any protein, enzyme or peptidic chain by simple peptide chemistry. This bioorganometallic systems were active as catalysts in the aldol reaction between methyl isocianate and benzaldehyde.
URI: http://hdl.handle.net/10045/39890
ISSN: 0040-4039 (Print) | 1873-3581 (Online)
DOI: 10.1016/S0040-4039(02)00656-1
Language: eng
Type: info:eu-repo/semantics/article
Peer Review: si
Publisher version: http://dx.doi.org/10.1016/S0040-4039(02)00656-1
Appears in Collections:INV - CESO - Artículos de Revistas

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