Choroidal Thickness And Volume In Healthy Young Whites And Their Relationship With Axial Length, Ammetropy And Sex

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Title: Choroidal Thickness And Volume In Healthy Young Whites And Their Relationship With Axial Length, Ammetropy And Sex
Authors: Sánchez Cano, Ana | Orduna, Elvira | Segura, Francisco | López, Carmen | Cuenca, Nicolás | Abecia, Emilio | Pinilla Lozano, Isabel
Research Group/s: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)
Center, Department or Service: Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología
Keywords: Choroidal thickness and volume | Young adults | EDI SD-OCT | Axial length | Myopic ammetropy
Knowledge Area: Biología Celular
Issue Date: 5-Jun-2014
Publisher: Elsevier
Citation: American Journal of Ophthalmology. 2014, Accepted Manuscript. doi:10.1016/j.ajo.2014.05.035
Abstract: Purpose: To evaluate choroidal thickness in young subjects using Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography (EDI SD-OCT) describing volume differences between all the defined areas of the Early Treatment Diabetic Retinopathy Study (ETDRS). Design: Prospective, clinical study. Methods: Seventy-nine eyes of 95 healthy, young (23.8±3.2years), adult volunteers were prospectively enrolled. Manual choroidal segmentation on a 25-raster horizontal scan protocol was performed. The measurements of the nine subfields defined by the ETDRS were evaluated. Results: Mean subfoveal choroidal thickness was 345.67±81.80μm and mean total choroidal volume was 8.99±1.88mm3. Choroidal thickness and volume were higher at the superior and temporal areas compared to inferior and nasal sectors of the same diameter respectively. Strong correlations between subfoveal choroidal thickness and axial length (AL) and myopic refractive error were obtained, r = -0.649, p<0.001 and r = 0.473, p<0.001 respectively. Emmetropic eyes tended to have thicker subfoveal choroidal thickness (381.94±79.88μm versus 307.04±64.91μm) and higher total choroidal volume than myopic eyes (9.80± 1.87mm3 versus 8.14±1.48mm3). The estimation of the variation of the subfoveal choroidal thickness with the AL was-43.84μm/mm. In the myopic group, the variation of the subfoveal choroidal thickness with the myopic refractive error was -10.45μm/D. Conclusions: This study establishes for the first time a normal database for choroidal thickness and volume in young adults. Axial length, and myopic ammetropy are highly associated with choroidal parameters in healthy subjects. EDI SD-OCT exhibited a high degree of intraobserver and interobserver repeatability.
Sponsor: Publication of this article was supported by the Diputación General de Aragón Group B99, and Fondo de Investigación Sanitaria Instituto de Salud Carlos III (Spanish Ministry of Health) PS0901854, PI13/01124 and Instituto de Salud Carlos III RETICS RD12/0034/0010. FS was supported by a University of Zaragoza grant FPUZ-2011-BIO-02.
ISSN: 0002-9394 (Print) | 1879-1891 (Online)
DOI: 10.1016/j.ajo.2014.05.035
Language: eng
Type: info:eu-repo/semantics/article
Peer Review: si
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Appears in Collections:INV - NEUROVIS - Artículos de Revistas

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