Organocatalytic enantioselective multicomponent reactions (OEMCRs)

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Title: Organocatalytic enantioselective multicomponent reactions (OEMCRs)
Authors: Guillena, Gabriela | Ramón, Diego J. | Yus, Miguel
Research Group/s: Derivados de Aminoácidos y Péptidos en Síntesis Orgánica
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica
Keywords: Organocatalysis | Multicomponent | Eenantioselective | Asymmetric synthesis | Amino acids | Proline
Knowledge Area: Química Orgánica
Date Created: 2007
Issue Date: 16-Apr-2007
Publisher: Elsevier
Citation: GUILLENA TOWNLEY, Gabriela; RAMÓN DANGLA, Diego José; YUS ASTIZ, Miguel. "Organocatalytic enantioselective multicomponent reactions (OEMCRs)". Tetrahedron: Asymmetry. Vol. 18, Issue 6 (16 Apr. 2007). ISSN 0957-4166, pp. 693-700
Abstract: The achieved level of expertise in organocatalytic processes has allowed synthetic chemists to apply this useful synthetic strategy to enantioselective multicomponent reactions. Although, this new methodology is still in its infancy, the reported results show the possibilities and versatility of this type of reaction, with an extraordinary level of atom efficiency being reached. All examples, from classical Mannich, Biginelli, Michael, and Diels–Alder reactions to new amination–reduction and Tietze reactions, allow the synthesis of complex chiral molecules with several stereogenic elements created in just one process. In fact, the organocatalyst acts in this type of process as a clear enzyme mimic, but with an ample substrate scope.
Sponsor: We are grateful to the Spanish Ministerio de Educación y Ciencia, as well as to Generalitat Valenciana, for their continuous financial support.
ISSN: 0957-4166
DOI: 10.1016/j.tetasy.2007.03.002
Language: eng
Type: info:eu-repo/semantics/article
Peer Review: si
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