Copper-catalysed multicomponent click synthesis of 5-alkynyl 1,2,3-triazoles under ambient conditions
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Title: | Copper-catalysed multicomponent click synthesis of 5-alkynyl 1,2,3-triazoles under ambient conditions |
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Authors: | Alonso, Francisco | Moglie, Yanina | Radivoy, Gabriel | Yus, Miguel |
Research Group/s: | Nuevas Metodologías en Síntesis Orgánica |
Center, Department or Service: | Universidad de Alicante. Departamento de Química Orgánica |
Keywords: | Alkynes | Alkyl halides | Azides | Cycloaddition | Copper | Cross-coupling | Heterocycles | Multicomponent reaction |
Knowledge Area: | Química Orgánica |
Date Created: | 2012 |
Issue Date: | 8-Aug-2012 |
Publisher: | Georg Thieme Verlag |
Citation: | ALONSO, Francisco, et al. "Copper-catalysed multicomponent click synthesis of 5-alkynyl 1,2,3-triazoles under ambient conditions". Synlett. Vol. 23, No. 15 (2012). ISSN 0936-5214, pp. 2179-2182 |
Abstract: | Copper(I) oxide has been found to effectively catalyse the multicomponent click synthesis of fully substituted 5-alkynyl 1,2,3-triazoles from organic halides, sodium azide, and terminal alkynes in methanol under ambient conditions. |
Sponsor: | This work was generously supported by the Spanish Ministerio de Ciencia e Innovación (MICINN; CTQ2007-65218 and Consolider Ingenio 2010-CSD2007-00006), the Generalitat Valenciana (GV; PROMETEO/2009/039), and Fondo Europeo de Desarrollo Regional (FEDER). Y. M. acknowledges the Instituto de Síntesis Orgánica (ISO) of the Universidad de Alicante for a grant. |
URI: | http://hdl.handle.net/10045/24175 |
ISSN: | 0936-5214 (Print) | 1437-2096 (Online) |
DOI: | 10.1055/s-0031-1290445 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Rights: | © Georg Thieme Verlag Stuttgart New York. http://www.thieme-connect.com/ejournals/toc/synlett |
Peer Review: | si |
Publisher version: | http://dx.doi.org/10.1055/s-0031-1290445 |
Appears in Collections: | INV - MESO - Artículos de Revistas INV - SINTAS - Artículos de Revistas INV - MATCAT - Artículos de Revistas |
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SYNLETT Copper-Catalysed Multicomponent Click Synthesis of 5-Alkynyl.pdf | Versión revisada (acceso abierto) | 194,68 kB | Adobe PDF | Open Preview |
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