Copper-catalysed multicomponent click synthesis of 5-alkynyl 1,2,3-triazoles under ambient conditions

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Title: Copper-catalysed multicomponent click synthesis of 5-alkynyl 1,2,3-triazoles under ambient conditions
Authors: Alonso, Francisco | Moglie, Yanina | Radivoy, Gabriel | Yus, Miguel
Research Group/s: Nuevas Metodologías en Síntesis Orgánica
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica
Keywords: Alkynes | Alkyl halides | Azides | Cycloaddition | Copper | Cross-coupling | Heterocycles | Multicomponent reaction
Knowledge Area: Química Orgánica
Date Created: 2012
Issue Date: 8-Aug-2012
Publisher: Georg Thieme Verlag
Citation: ALONSO, Francisco, et al. "Copper-catalysed multicomponent click synthesis of 5-alkynyl 1,2,3-triazoles under ambient conditions". Synlett. Vol. 23, No. 15 (2012). ISSN 0936-5214, pp. 2179-2182
Abstract: Copper(I) oxide has been found to effectively catalyse the multicomponent click synthesis of fully substituted 5-alkynyl 1,2,3-triazoles from organic halides, sodium azide, and terminal ­alkynes in methanol under ambient conditions.
Sponsor: This work was generously supported by the Spanish Ministerio de Ciencia e Innovación (MICINN; CTQ2007-65218 and Consolider Ingenio 2010-CSD2007-00006), the Generalitat Valenciana (GV; PROMETEO/2009/039), and Fondo Europeo de Desarrollo Regional (FEDER). Y. M. acknowledges the Instituto de Síntesis Orgánica (ISO) of the Universidad de Alicante for a grant.
ISSN: 0936-5214 (Print) | 1437-2096 (Online)
DOI: 10.1055/s-0031-1290445
Language: eng
Type: info:eu-repo/semantics/article
Rights: © Georg Thieme Verlag Stuttgart New York.
Peer Review: si
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