Formation and dissolution of spinules and changes in nematosome size require optic nerve integrity in black bass (Micropterus salmoides) retina

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Title: Formation and dissolution of spinules and changes in nematosome size require optic nerve integrity in black bass (Micropterus salmoides) retina
Authors: Juan Herrero, Joaquín de | García Irles, Magdalena | Cuenca, Nicolás
Research Group/s: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) | Biotecnología
Center, Department or Service: Universidad de Alicante. Departamento de Biotecnología | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología
Keywords: Cone pedicle | Horizontal cell | Synaptic plasticity | Dopamine | Nucleolus-like body | Light- and dark-adaptation | Efferent fiber
Knowledge Area: Oftalmología | Fisiología
Issue Date: 29-Jan-1996
Publisher: Elsevier
Citation: JUAN HERRERO, Joaquín de; GARCÍA IRLES, Magdalena; CUENCA NAVARRO, Nicolás. "Formation and dissolution of spinules and changes in nematosome size require optic nerve integrity in black bass (Micropterus salmoides) retina". Brain Research. Vol. 707, Issue 2 (29 Jan. 1996). ISSN 0006-8993, pp. 213-220
Abstract: Teleost retinas adapted to light show numerous spinules invaginated in the cone pedicles and small nematosomes in the distal horizontal cells. Darkness induces the dissolution of spinules and the presence of large and numerous nematosomes. The aim of this work is to study the influence of optic nerve integrity on spinule formation/dissolution and changes in nematosome size during light or dark adaptation of black bass (Micropterus salmoides) retinas. Eyes from fish, dark- or light-adapted, were removed and the eyecups placed in oxygenated Ringer's solution and immediately exposed to light or dark, respectively, for 1 h. The number of spinules per pedicle and the nematosome diameter were measured on electron micrographs. Isolation of eyecups in the dark, impaired both spinule formation and nematosome size reduction when they were superfused in light. In the same way, isolation of eyecups in the light, impaired both spinule dissolution and nematosome size increase when they were superfused in dark. No significant differences in spinule number and nematosome size, following dopamine superfusion, were found in comparison to retinas superfused with Ringer's solution only. Our results suggest: (1) optic nerve integrity is necessary to yield spinule formation/disruption and changes in nematosome size during light or dark adaptation. (2) dopamine does not appear to be the primary agent responsible for spinule formation.
Sponsor: This research was supported by DGICYT Grant PM92-0113 and GV-2521-94 to J.D.J.
URI: http://hdl.handle.net/10045/17027
ISSN: 0006-8993 (Print) | 1872-6240 (Online)
DOI: 10.1016/0006-8993(95)01259-1
Language: eng
Type: info:eu-repo/semantics/article
Peer Review: si
Publisher version: http://dx.doi.org/10.1016/0006-8993(95)01259-1
Appears in Collections:INV - NEUROVIS - Artículos de Revistas
INV - GIDBT - Artículos de Revistas
INV - Grupo de Inmunología - Artículos de Revistas
Institucional - IUIEG - Publicaciones

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