Endothelial nitric oxide synthase (eNOS) is localized to Müller cells in all vertebrate retinas

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Title: Endothelial nitric oxide synthase (eNOS) is localized to Müller cells in all vertebrate retinas
Authors: Haverkamp, Silke | Kolb, Helga | Cuenca, Nicolás
Research Group/s: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)
Center, Department or Service: Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología
Keywords: Immunostaining | Glial cells | Astrocytes | Horizontal cell axon terminals
Knowledge Area: Oftalmología | Fisiología
Issue Date: 1-Apr-1999
Publisher: Elsevier
Citation: HAVERKAMP, Silke; KOLB, Helga; CUENCA NAVARRO, Nicolás. "Endothelial nitric oxide synthase (eNOS) is localized to Müller cells in all vertebrate retinas". Vision Research. Vol. 39, Issue 14 (June 1999). ISSN 0042-6989, pp. 2299-2303
Abstract: The distribution of endothelial nitric oxide synthase immunoreactivity (eNOS-IR) was investigated in the retinas of all phylogenetic vertebrate classes by using a monoclonal eNOS antibody. Confocal light microscopy showed immunoreactive labeling in Müller cells of fish, frog, salamander, turtle, chicken, rat, ground squirrel, and monkey retina. In vascularized retinas (rat, monkey), astrocytes and some blood vessels were also stained. Furthermore, eNOS-IR was localized to axon terminals of turtle and fish horizontal cells. These observations are the first to show the presence of eNOS-IR in Muller glia and horizontal cell structures of the vertebrate retina.
Sponsor: Supported by grants EY03323 and EY04855 and a grant from Research to Prevent Blindness to the Department of Ophthalmology, Moran Eye Center.
URI: http://hdl.handle.net/10045/16788
ISSN: 0042-6989 (Print) | 1878-5646 (Online)
DOI: 10.1016/S0042-6989(99)00007-3
Language: eng
Type: info:eu-repo/semantics/article
Peer Review: si
Publisher version: http://dx.doi.org/10.1016/S0042-6989(99)00007-3
Appears in Collections:INV - NEUROVIS - Artículos de Revistas

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