Choline acetyltransferase is expressed by non-starburst amacrine cells in the ground squirrel retina

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Títol: Choline acetyltransferase is expressed by non-starburst amacrine cells in the ground squirrel retina
Autors: Cuenca, Nicolás | Deng, Ping | Linberg, Ken A. | Fisher, Steven K. | Kolb, Helga
Grups d'investigació o GITE: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)
Centre, Departament o Servei: Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología
Paraules clau: Retina | Amacrine cell | Choline acetyltransferase | Immunostaining
Àrees de coneixement: Oftalmología | Fisiología
Data de publicació: 31-de desembre-2002
Editor: Elsevier
Citació bibliogràfica: CUENCA NAVARRO, Nicolás, et al. "Choline acetyltransferase is expressed by non-starburst amacrine cells in the ground squirrel retina". Brain Research. Vol. 964, Issue 1 (21 Febr. 2003). ISSN 0006-8993, pp. 21-30
Resum: We have used immunostaining techniques to reveal a new type of amacrine cell that is immunoreactive for choline acetyltransferase (ChAT), the acetylcholine synthesizing enzyme, in the Ground Squirrel (Spermophilus beecheyi) retina. Cryostat sections and double immunostained wholemount preparations were examined by confocal microscopy. This new ChAT type III cell is distinct in morphology and neurotransmitter content from the well know ‘starburst’ amacrine cells (types I and II) that are so well represented in the ground squirrel retina [J. Comp. Neurol. 365 (1996) 173–216]. The type III cell colocalizes glycine with the acetylcholine and does not appear to be GABAergic or exhibit calcium-binding proteins like the well-known starburst type. As well, type III cells do not occur as a mirror-symmetric pair with normally placed and displaced varieties. The type III cell is probably a small field amacrine type branching broadly in upper sublamina b of the inner plexiform layer, and is most likely A6 of the Ground Squirrel retina [J. Comp. Neurol. 365 (1996) 173–216]. Type III cells are ideally placed in the architecture of the Ground Squirrel retina to influence ON directionally selective ganglion cell types.
Patrocinadors: Supported by Research to Prevent Blindness to HK and DGESIC PB98-0972 to NC.
ISSN: 0006-8993 (Print) | 1872-6240 (Online)
DOI: 10.1016/S0006-8993(02)04049-0
Idioma: eng
Tipus: info:eu-repo/semantics/article
Revisió científica: si
Versió de l'editor:
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