Morphological impairments in retinal neurons of the scotopic visual pathway in a monkey model of Parkinson's disease
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Campo DC | Valor | Idioma |
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dc.contributor | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) | en |
dc.contributor | Genética Humana y de Mamíferos (GHM) | en |
dc.contributor.author | Cuenca, Nicolás | - |
dc.contributor.author | Herrero Ezquerro, María Trinidad | - |
dc.contributor.author | Angulo Jerez, Antonia | - |
dc.contributor.author | Juan Navarro, Emilio de | - |
dc.contributor.author | Martínez Navarrete, Gema Concepción | - |
dc.contributor.author | López Tomás, Salvador | - |
dc.contributor.author | Barcia González, Carlos | - |
dc.contributor.author | Martín-Nieto, José | - |
dc.contributor.other | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | en |
dc.contributor.other | Universidad de Alicante. Departamento de Biotecnología | en |
dc.contributor.other | Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía | en |
dc.date.accessioned | 2011-03-24T11:42:09Z | - |
dc.date.available | 2011-03-24T11:42:09Z | - |
dc.date.issued | 2005-10-27 | - |
dc.identifier.citation | CUENCA NAVARRO, Nicolás, et al. "Morphological impairments in retinal neurons of the scotopic visual pathway in a monkey model of Parkinson's disease". The Journal of Comparative Neurology. Vol. 493, No. 2 (12 Dec. 2005). ISSN 0021-9967, pp. 261-273 | en |
dc.identifier.issn | 0021-9967 (Print) | - |
dc.identifier.issn | 1096-9861 (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/16762 | - |
dc.description.abstract | Physiological abnormalities resulting from death of dopaminergic neurons of the central nervous system in Parkinson's disease also extend to the retina, resulting in impaired visual functions. In both parkinsonian patients and animal models, low levels of dopamine and loss of dopaminergic cells in the retina have been reported. However, the morphology and connectivity of their postsynaptic neurons, the amacrine cells, have not been analyzed. Here we report, with macaques chronically treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a model of Parkinson's disease, that morphological impairments in dopaminergic retinal neurons and their plexus in the inner retina are accompanied by an immunoreactivity decrease in γ-aminobutyric acidergic and glycinergic amacrine cells. Especially deteriorated were AII amacrine cells, the main neuronal subtype postsynaptic to dopaminergic cells, which exhibited a marked loss of lobular appendages and dendritic processes. Concomitantly, electrical synapses among AII cells, as well as chemical synapses between these and rod bipolar cells, were highly deteriorated in parkinsonian monkeys. These results highlight that the scotopic visual pathway is severely impaired in the parkinsonian condition and provide a morphological basis for a number of abnormalities found in electrophysiological and psychophysical trials in Parkinson's disease patients and animal models. | en |
dc.description.sponsorship | Ministerio de Ciencia y Tecnología, Spain; Grant number: BFI2003-01404 (to N.C.); Grant sponsor: Generalitat Valenciana, Spain; Grant number: CTIDIB/2002/146 (to N.C.); Grant number: GV04B/452 (to J.M.-N.). | en |
dc.language | eng | en |
dc.publisher | Wiley-Liss, Inc. | en |
dc.rights | The definitive version is available at www3.interscience.wiley.com | en |
dc.subject | Parkinsonian monkeys | en |
dc.subject | Retina | en |
dc.subject | Dopaminergic neurons | en |
dc.subject | AII amacrines | en |
dc.subject | Connexin-36 | en |
dc.subject.other | Oftalmología | en |
dc.subject.other | Fisiología | en |
dc.title | Morphological impairments in retinal neurons of the scotopic visual pathway in a monkey model of Parkinson's disease | en |
dc.type | info:eu-repo/semantics/article | en |
dc.peerreviewed | si | en |
dc.identifier.doi | 10.1002/cne.20761 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1002/cne.20761 | en |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | en |
Aparece en las colecciones: | INV - NEUROVIS - Artículos de Revistas INV - GHM - Artículos de Revistas |
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