Hospitalization risk among patients with Mpox infection—a propensity score matched analysis

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Title: Hospitalization risk among patients with Mpox infection—a propensity score matched analysis
Authors: Henao-Martinez, Andres F. | Orkin, Chloe M. | Titanji, Boghuma K. | Rodriguez-Morales, Alfonso J. | Salinas, Jorge L. | Franco-Paredes, Carlos | Tuells, José | Chastain, Daniel B.
Research Group/s: Salud Comunitaria (SALUD)
Center, Department or Service: Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia
Keywords: Mpox | Monkeypox virus | HIV/AIDS | Hospitalization
Issue Date: 30-Aug-2023
Publisher: SAGE Publications
Citation: Therapeutic Advances in Infectious Disease. 2023.
Abstract: Background: Monkeypox (Mpox) is a reemerging, neglected viral disease. By May 2023, worldwide Mpox cases surpassed 87,000. Predictive factors for hospitalization with Mpox are lacking. Objective: We aim to compare clinical characteristics and outcomes in hospitalized and nonhospitalized patients with Mpox infection. Design: A multicenter retrospective case-control cohort of patients with Mpox infection. Methods: We performed a propensity score match analysis from a global health network (TrinetX). We compare clinical characteristics and outcomes between hospitalized and nonhospitalized patients with Mpox. Results: Of 1477 patients, 6% were hospitalized, 52% required an ED visit, and 29% received treatment at urgent care. After propensity score matching, 80 patients remained in each group. Hospitalizations were more common among Black persons (51% versus 33%, p = 0.01), people with HIV (50% versus 20%, p < 0.0001), and those with proctitis (44% versus 12.5%, p < 0.001). Conclusion: Independent predictive factors of hospitalization in our cohort for Mpox included people who are Black with a diagnosis of HIV, severe proctitis, pain requiring opioids, and elevated lactate dehydrogenase. Greater recognition of factors associated with increased risk of Mpox severity and hospitalization is paramount.
Sponsor: Dr. Boghuma K. Titanji is funded by the NIH BIRCWH program and Emory CFAR grant P30AI050509).
ISSN: 2049-9361 (Print) | 2049-937X (Online)
DOI: 10.1177/20499361231196683
Language: eng
Type: info:eu-repo/semantics/article
Rights: © The Author(s), 2023. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the Sage and Open Access pages (
Peer Review: si
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Appears in Collections:INV - SALUD - Artículos de Revistas

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