MicroRNAs in the Mouse Developing Retina

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Title: MicroRNAs in the Mouse Developing Retina
Authors: Navarro-Calvo, Jorge | Esquiva, Gema | Gómez-Vicente, Violeta | Valor, Luis M.
Research Group/s: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)
Center, Department or Service: Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía
Keywords: Retina | Mouse | Dicer | miR-183/96/182 | miR-204/211 | miR-124 | miR-9 | let-7 | Transcriptomics
Issue Date: 3-Feb-2023
Publisher: MDPI
Citation: Navarro-Calvo J, Esquiva G, Gómez-Vicente V, Valor LM. MicroRNAs in the Mouse Developing Retina. International Journal of Molecular Sciences. 2023; 24(3):2992. https://doi.org/10.3390/ijms24032992
Abstract: The retina is among the highest organized tissues of the central nervous system. To achieve such organization, a finely tuned regulation of developmental processes is required to form the retinal layers that contain the specialized neurons and supporting glial cells to allow precise phototransduction. MicroRNAs are a class of small RNAs with undoubtful roles in fundamental biological processes, including neurodevelopment of the brain and the retina. This review provides a short overview of the most important findings regarding microRNAs in the regulation of retinal development, from the developmental-dependent rearrangement of the microRNA expression program to the key roles of particular microRNAs in the differentiation and maintenance of retinal cell subtypes.
Sponsor: This research was funded by Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I + D + i financed by Instituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional 2014–2020 (grant PI19/00125), Ayudas para el Apoyo y Fomento de la Investigación financed by ISABIAL (grant 2021-0406), and Ayudas para proyectos emergentes de la GVA (GV/2020/064). L.M.V. is the recipient of a Miguel Servet II contract (CPII20/00025), financed by Instituto de Salud Carlos III and Fondo Social Europeo 2014–2020, Programa Estatal de Promoción del Talento y su empleabilidad en I + D + i.
URI: http://hdl.handle.net/10045/132665
ISSN: 1422-0067
DOI: 10.3390/ijms24032992
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Peer Review: si
Publisher version: https://doi.org/10.3390/ijms24032992
Appears in Collections:INV - NEUROVIS - Artículos de Revistas

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