Wittig-type olefination of alcohols promoted by nickel nanoparticles: synthesis of polymethoxylated and polyhydroxylated stilbenes
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Title: | Wittig-type olefination of alcohols promoted by nickel nanoparticles: synthesis of polymethoxylated and polyhydroxylated stilbenes |
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Authors: | Alonso, Francisco | Riente Paiva, Paola | Yus, Miguel |
Research Group/s: | Nuevas Metodologías en Síntesis Orgánica |
Center, Department or Service: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
Keywords: | Alcohols | Olefination | Nickel | Nanoparticles | Wittig reactions |
Knowledge Area: | Química Orgánica |
Date Created: | 2009 |
Issue Date: | 8-Oct-2009 |
Publisher: | Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim |
Citation: | ALONSO VALDÉS, Francisco; RIENTE PAIVA, Paola; YUS ASTIZ, Miguel. "Wittig-type olefination of alcohols promoted by nickel nanoparticles: synthesis of polymethoxylated and polyhydroxylated stilbenes". European Journal of Organic Chemistry. Vol. 2009, Issue 34 (Oct. 2009). ISSN 1434-193X, pp. 6034-6042 |
Abstract: | Nickel nanoparticles were found to promote the Wittig-type olefination of primary alcohols with phosphorus ylides. The latter can be prepared from the corresponding phosphonium salts with nBuLi or in situ generated with lithium metal. The methodology is especially efficient for the synthesis of stilbenes and is applied in the absence of any additive as ahydrogen acceptor. A new approach to the synthesis of polymethoxylated and polyhydroxylated stilbenes, including resveratrol, DMU-212 and analogues, is presented. |
Sponsor: | Spanish Ministerio de Educación y Ciencia (MEC); Grant Number: CTQ2007-65218, CSD2007-00006. |
URI: | http://hdl.handle.net/10045/12846 |
ISSN: | 1434-193X (Print) | 1099-0690 (Online) |
DOI: | 10.1002/ejoc.200900951 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Peer Review: | si |
Publisher version: | http://www.interscience.wiley.com/ |
Appears in Collections: | INV - MESO - Artículos de Revistas INV - SINTAS - Artículos de Revistas INV - MATCAT - Artículos de Revistas |
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article2.pdf | Versión final (acceso restringido) | 350,67 kB | Adobe PDF | Open Request a copy |
proofs1.pdf | Versión revisada (acceso libre) | 370,25 kB | Adobe PDF | Open Preview |
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