Neuroprotective Effects of Tauroursodeoxicholic Acid Involves Vascular and Glial Changes in Retinitis Pigmentosa Model

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dc.contributorNeurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)es_ES
dc.contributor.authorFernández-Sánchez, Laura-
dc.contributor.authorAlbertos Arranz, Henar-
dc.contributor.authorOrtuño-Lizarán, Isabel-
dc.contributor.authorLax, Pedro-
dc.contributor.authorCuenca, Nicolás-
dc.contributor.otherUniversidad de Alicante. Departamento de Óptica, Farmacología y Anatomíaes_ES
dc.contributor.otherUniversidad de Alicante. Departamento de Fisiología, Genética y Microbiologíaes_ES
dc.identifier.citationFernández-Sánchez L, Albertos-Arranz H, Ortuño-Lizarán I, Lax P and Cuenca N (2022) Neuroprotective Effects of Tauroursodeoxicholic Acid Involves Vascular and Glial Changes in Retinitis Pigmentosa Model. Front. Neuroanat. 16:858073. doi: 10.3389/fnana.2022.858073es_ES
dc.description.abstractPurpose: Retinitis pigmentosa is primarily characterized by a massive photoreceptor loss. But a global retinal remodeling occurs in later stages of the disease. At that phase, glial cells and retinal vasculature are also strongly affected. The main aim of the present work is to assess if the bile acid Tauroursodeoxicholic acid (TUDCA), which has a demonstrated neuroprotective effect in numerous neurodegenerative diseases, is able to prevent glial and vascular degeneration in the P23H rat retina. Methods: Homozygous P23H (line 3) animals were injected weekly with a TUDCA (500 mg/kg, i.p.) or vehicle solution, from the postnatal day (P) 21 to P120. Sprague-Dawley rats (SD) were used as control. Retinal cross-sections and wholemounts were immunostained using different glial and vascular markers and visualized with confocal microscopy. Retinal blood vessels were stained with nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase histochemistry and retinal vascular networks were drawn by hand using a camera lucida. Results: At P120, the photoreceptor degeneration observed in P23H rats was accompanied by a reduction in the vascular network density and complexity at the deep capillary plexus. In addition, astrocytes showed gliotic features and the outer processes of Müller cells displayed an aberrant distribution in ring-shaped structures. When treated with TUDCA, P23H rats displayed better-preserved vessels and capillary loops in the deep capillary plexus which are associated with the partial preservation of photoreceptors. TUDCA treatment also increased the number of astrocytes and reduced the presence of Müller cell process clusters in the outer retina. Conclusion: This work suggests that, besides its neuroprotective effect on photoreceptor cells, TUDCA treatment also protects from vascular and glial degeneration, a fact that encourages the use of TUDCA as a powerful therapy for neurodegenerative diseases.es_ES
dc.description.sponsorshipThe authors also acknowledge support from grants funded by the Spanish Ministry of Science and Innovation (FEDER-PID2019-106230RB-I00), Spanish Ministry of Universities (FPU18/02964), National Institute of Health Carlos III (RETICS-FEDER RD16/0008/0016), and Generalitat Valenciana (IDIFEDER/2017/064, PROMETEO/2021/024, GV/2020/028, and APOSTD/2020/245).es_ES
dc.publisherFrontiers Mediaes_ES
dc.rights© 2022 Fernández-Sánchez, Albertos-Arranz, Ortuño-Lizarán, Lax and Cuenca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.es_ES
dc.subjectNeurovascular unites_ES
dc.subjectVascular networkes_ES
dc.subjectNeurodegenerative diseaseses_ES
dc.subjectBile acidses_ES
dc.subject.otherBiología Celulares_ES
dc.titleNeuroprotective Effects of Tauroursodeoxicholic Acid Involves Vascular and Glial Changes in Retinitis Pigmentosa Modeles_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106230RB-I00es_ES
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