Deciphering Pathways for Carotenogenesis in Haloarchaea
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Título: | Deciphering Pathways for Carotenogenesis in Haloarchaea |
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Autor/es: | Giani, Micaela | Miralles-Robledillo, José María | Peiró, Gloria | Pire, Carmen | Martínez-Espinosa, Rosa María |
Grupo/s de investigación o GITE: | Bioquímica Aplicada/Applied Biochemistry (AppBiochem) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Agroquímica y Bioquímica |
Palabras clave: | Carotenogenesis | Bacterioruberin | Natural pigments | Haloarchaea | Carotenoids | Antioxidant |
Área/s de conocimiento: | Bioquímica y Biología Molecular |
Fecha de publicación: | 6-mar-2020 |
Editor: | MDPI |
Cita bibliográfica: | Giani M, Miralles-Robledillo JM, Peiró G, Pire C, Martínez-Espinosa RM. Deciphering Pathways for Carotenogenesis in Haloarchaea. Molecules. 2020; 25(5):1197. doi:10.3390/molecules25051197 |
Resumen: | Bacterioruberin and its derivatives have been described as the major carotenoids produced by haloarchaea (halophilic microbes belonging to the Archaea domain). Recently, different works have revealed that some haloarchaea synthetize other carotenoids at very low concentrations, like lycopene, lycopersene, cis- and trans-phytoene, cis- and trans-phytofluene, neo-β-carotene, and neo-α-carotene. However, there is still controversy about the nature of the pathways for carotenogenesis in haloarchaea. During the last decade, the number of haloarchaeal genomes fully sequenced and assembled has increased significantly. Although some of these genomes are not fully annotated, and many others are drafts, this information provides a new approach to exploring the capability of haloarchaea to produce carotenoids. This work conducts a deeply bioinformatic analysis to establish a hypothetical metabolic map connecting all the potential pathways involved in carotenogenesis in haloarchaea. Special interest has been focused on the synthesis of bacterioruberin in members of the Haloferax genus. The main finding is that in almost all the genus analyzed, a functioning alternative mevalonic acid (MVA) pathway provides isopentenyl pyrophosphate (IPP) in haloarchaea. Then, the main branch to synthesized carotenoids proceeds up to lycopene from which β-carotene or bacterioruberin (and its precursors: monoanhydrobacterioriberin, bisanhydrobacterioruberin, dihydrobisanhydrobacteriuberin, isopentenyldehydrorhodopsin, and dihydroisopenthenyldehydrorhodopsin) can be made. |
Patrocinador/es: | This work was partially funded by research grants from MINECO Spain (RTI2018-099860-B-I00) and the University of Alicante (VIGROB-309). |
URI: | http://hdl.handle.net/10045/103887 |
ISSN: | 1420-3049 |
DOI: | 10.3390/molecules25051197 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3390/molecules25051197 |
Aparece en las colecciones: | INV - AppBiochem - Artículos de Revistas |
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