Belveren, Samet, Poyraz, Samet, Pask, Christopher M., Ülger, Mahmut, Sansano, Jose M., Dondas, H. Ali
Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moieties
Inorganica Chimica Acta. 2019, 498: 119154. doi:10.1016/j.ica.2019.119154
URI: http://hdl.handle.net/10045/96887
DOI: 10.1016/j.ica.2019.119154
ISSN: 0020-1693 (Print)
Abstract: 
Platinum complexes, derived from two families of bidentate funcionalized aroylaminocarbo-N-thyoyl prolinates, are prepared using mild conditions from prolinates, which are available via 1,3-dipolar cycloadditions. The resulting four coordinated neutral square-planar platinum(II) complexes are very stable and are fully characterized. Their structures are determined by spectroscopic and analytical methods and one of them by single crystal X-ray diffraction analysis. In this pattern, the platinum exhibits distorted square planar geometry, with cis-bond angles ranging from 89.42(2) and 94.37(6)° and trans-bond angles of 176.19(6) and 177.08(6)°, respectively. Anti(myco)bacterial and antifungal studies of all these new compounds are carried out under standardized protocols.
Keywords:Platinum complexes, Aminocarbothiol, Antibacterial, Antifungal
Elsevier
info:eu-repo/semantics/article