Sbei, Najwa, Batanero, Belén, Barba, Fructuoso, Haouas, Beya, Benkhoud, Mohamed Lamine, Barba, Isidoro
Facile preparation of 3-substituted 2-quinazolinones via electrogenerated base
Tetrahedron. 2018, 74(16): 2068-2072. doi:10.1016/j.tet.2018.03.010
URI: http://hdl.handle.net/10045/77549
DOI: 10.1016/j.tet.2018.03.010
ISSN: 0040-4020 (Print)
Abstract: 
A new series of 3,4-disubstituted quinazolin-2-ones, with potential T-type calcium channel antagonist activity, and new 4-methylene-quinazolin-2-ones, promising catalysts as N-heterocyclic olefins, have been prepared in good yield by a simple reaction between 2-aminobenzophenone, or 2-aminoacetophenone, and cyanomethyl anion electrogenerated by acetonitrile reduction at a graphite electrode, followed by the addition of different organic isocyanates and subsequent heterocyclization.
Keywords:Quinazolin-2-ones, N-heterocyclic olefins, Magnesium sacrificial anode, Electrogenerated cyanomethyl anion, Organic isocyanates
Elsevier
info:eu-repo/semantics/article