Freckleton, Megan, Baeza, Alejandro, Benavent, Llorenç, Chinchilla, Rafael
Asymmetric Organocatalytic Electrophilic Heterofunctionalization of Oxindoles
Asian Journal of Organic Chemistry. 2018, 7(6): 1006-1014. doi:10.1002/ajoc.201800146
URI: http://hdl.handle.net/10045/76747
DOI: 10.1002/ajoc.201800146
ISSN: 2193-5807 (Print)
Abstract: 
The asymmetric synthesis of 3‐substituted oxindoles is a topic of considerable importance because these functionalized heterocycles are found in many natural products and drugs. In the last decade, significant advances have been made towards the asymmetric synthesis of 3‐heteroatom‐substituted oxindoles as a result of major improvements in asymmetric organocatalysis. This review will focus on the different types of asymmetric electrophilic organocatalyzed reactions, including the amination, halogenation, hydroxylation, and sulfenylation of oxindoles to form their enantioenriched 3‐heterosubstituted derivatives.
Keywords:Asymmetric catalysis, Heterocycles, Heterofunctionalization, Organocatalysis, Quaternary stereocenters
Wiley-VCH Verlag GmbH & Co. KGaA
info:eu-repo/semantics/article