Prieto, Daniel, Carpena, Núria, Maneu, Victoria, Gil, María Luisa, Pla, Jesús, Gozalbo, Daniel
TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model
Microbes and Infection. 2016, 18(10): 656-660. doi:10.1016/j.micinf.2016.05.005
URI: http://hdl.handle.net/10045/62750
DOI: 10.1016/j.micinf.2016.05.005
ISSN: 1286-4579 (Print)
Abstract: 
Invasive candidiasis often arises from translocation of endogenous yeasts from the gastrointestinal tract to the bloodstream. Here we describe that both wild type and TLR2−/− mice strains, orally administered with Candida albicans yeasts, display similar sustained high level of gut colonization when oral antibacterial treatment is present, while removal of antibiotic treatment causes a progressive clearance of yeasts in control but not in TLR2−/− mice. Fungal invasion of internal organs, following immunosuppression of colonized mice, was increased in TLR2−/− mice. These results point out to a role of TLR2 in gut protection against colonization and endogenous invasion by C. albicans.
Keywords:Candida albicans, Gut colonization, TLR2, Immunosuppressed mice
Elsevier
info:eu-repo/semantics/article