Ramírez, Nieves P., Bosque, Irene, Gonzalez-Gomez, Jose C.
Photocatalytic Dehydrogenative Lactonization of 2-Arylbenzoic Acids
Organic Letters. 2015, 17(18): 4550-4553. doi:10.1021/acs.orglett.5b02269
URI: http://hdl.handle.net/10045/52884
DOI: 10.1021/acs.orglett.5b02269
ISSN: 1523-7060 (Print)
Abstract: 
A metal-free dehydrogenative lactonization of 2-arylbenzoic acids at room temperature was developed. This work illustrates the first application of visible-light photoredox catalysis in the preparation of benzo-3,4-coumarins, an important structural motif in bioactive molecules. The combination of photocatalyst [Acr+-Mes] with (NH4)2S2O8 as a terminal oxidant provides an economical and environmentally benign entry to different substituted benzocoumarins. Preliminary mechanistic studies suggest that this reaction most likely occurs through a homolytic aromatic substitution pathway.
Keywords:Photocatalytic, Dehydrogenative, Lactonization, 2-arylbenzoic acids
American Chemical Society
info:eu-repo/semantics/article