Trillo Alarcón, María Paz, Baeza, Alejandro, Nájera, Carmen
Copper-Catalyzed Asymmetric Alkylation of β-Keto Esters with Xanthydrols
Advanced Synthesis & Catalysis. 2013, 355(14-15): 2815-2821. doi:10.1002/adsc.201300627
URI: http://hdl.handle.net/10045/40228
DOI: 10.1002/adsc.201300627
ISSN: 1615-4150 (Print)
Abstract: 
The copper(II) triflate-tert-butyl-bisoxazoline [Cu(OTf)2-t-Bu-BOX]-catalyzed asymmetric alkylation of β-keto esters using free benzylic alcohols such as xanthydrols, as alkylating agents, is herein described for the first time. This green protocol renders in general the corresponding products with good results in terms of both yields and enantioselectivities using different keto esters, even when quaternary stereocenters were created. The scope, limitations and mechanistic aspects of the process are also discussed.
Keywords:Alcohols, Asymmetric alkylation, Bisoxazolines, Copper, β-keto esters
Wiley-VCH Verlag GmbH & Co. KGaA
info:eu-repo/semantics/article