Cívicos García, José Francisco, Alonso, Diego A., Nájera, Carmen
Microwave-Promoted Copper-Free Sonogashira–Hagihara Couplings of Aryl Imidazolylsulfonates in Water
Advanced Synthesis & Catalysis. 2013, 355(1): 203-208. doi:10.1002/adsc.201200629
URI: http://hdl.handle.net/10045/38196
DOI: 10.1002/adsc.201200629
ISSN: 1615-4150 (Print)
Abstract: 
Aryl imidazol-1-ylsulfonates have been efficiently cross-coupled with aryl-, alkyl-, and silylacetylenes in neat water under copper-free conditions at 110 °C assisted by microwave irradiation. Using 0.5 mol% of an oxime palladacycle as precatalyst, 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (SPhos, 2 mol%) as ligand, hexadecyltrimethylammonium bromide (CTAB) as additive, and triethylamine (TEA) as base, a wide array of disubstituted alkynes has been prepared in good to high yields in only 30 min.
Keywords:Cross-coupling, Microwave chemistry, Palladacycles, Sonogashira–Hagihara reaction, Water
Wiley-VCH Verlag GmbH & Co. KGaA
info:eu-repo/semantics/article