Guillena, Gabriela, Hita López, María del Carmen, Nájera, Carmen, Viózquez Cámara, Santiago Fidel
Solvent-free asymmetric direct aldol reactions organocatalysed by recoverable (Sa)-binam-L-prolinamide
GUILLENA TOWNLEY, Gabriela, et al. "Solvent-free asymmetric direct aldol reactions organocatalysed by recoverable (Sa)-binam-L-prolinamide". Tetrahedron: Asymmetry. Vol. 18, Issue 19 (27 Sept. 2007). ISSN 0957-4166, pp. 2300-2304
URI: http://hdl.handle.net/10045/2508
DOI: 10.1016/j.tetasy.2007.09.020
ISSN: 0957-4166
Abstract: 
The combination of (Sa)-binam-L-Pro (5 mol %) and benzoic acid (10 mol %) was used as catalysts in the direct aldol reaction
between different aliphatic ketones and 4-nitrobenzaldehyde under solvent-free reaction conditions. Three different procedures are
assayed: magnetic stirring (method A), magnetic stirring after previous dissolution in THF and evaporation (method B), and ball mill
technique (method C), methods A and B being the simplest. These reaction conditions allowed us to reduce the amount of required
ketone to 2 equiv to give the aldol product in similar reaction times and regio-, diastero-, and enantioselectivities than in organic or aqueous
solvents.
Keywords:Organocatalysis, Aldol, Enantioselective, Asymmetric synthesis, Amino acids, Proline
Elsevier
info:eu-repo/semantics/article