Palladium Mesoionic Carbene Pre-catalyst for General Cross-Coupling Transformations in Deep Eutectic Solvents

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Title: Palladium Mesoionic Carbene Pre-catalyst for General Cross-Coupling Transformations in Deep Eutectic Solvents
Authors: Marset, Xavier | Saavedra, Beatriz | González-Gallardo, Nerea | Beaton, Alexander | León, Martín M. | Luna, Raúl | Ramón, Diego J. | Guillena, Gabriela
Research Group/s: Alternative Methodologies In Chemistry (AMIC) | Nuevos Materiales y Catalizadores (MATCAT) | Catálisis Estereoselectiva en Síntesis Orgánica (CESO)
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Keywords: Mesoionic carbene | Palladium | Deep Eutectic Solvent | Sustainability | Cross-coupling reaction
Knowledge Area: Química Orgánica
Issue Date: 23-Oct-2019
Publisher: Frontiers Media
Citation: Marset X, Saavedra B, González-Gallardo N, Beaton A, León MM, Luna R, Ramón DJ and Guillena G (2019) Palladium Mesoionic Carbene Pre-catalyst for General Cross-Coupling Transformations in Deep Eutectic Solvents. Front. Chem. 7:700. doi: 10.3389/fchem.2019.00700
Abstract: A strong σ-donor mesoionic carbene ligand has been synthesized and applied to four different palladium-catalyzed cross-coupling transformations, proving the catalyst/medium compatibility and the increased activity of this system over previous reports in Deep Eutectic Solvent medium. Some cross-coupling processes could be carried out at room temperature and using aryl chlorides as starting materials. The possible implementation of multistep synthesis in eutectic mixtures has also been explored. The presence of palladium nanoparticles in the reaction media has been evaluated and correlated to the observed activity.
Sponsor: This work was supported by the Spanish Ministerio de Economía, Industria y Competitividad (CTQ2015-66624-P and PGC2018-096616-B-I00) and the University of Alicante (VIGROB-316).
URI: http://hdl.handle.net/10045/97811
ISSN: 2296-2646
DOI: 10.3389/fchem.2019.00700
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2019 Marset, Saavedra, González-Gallardo, Beaton, León, Luna, Ramón and Guillena. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Peer Review: si
Publisher version: https://doi.org/10.3389/fchem.2019.00700
Appears in Collections:INV - CESO - Artículos de Revistas
INV - AMIC - Artículos de Revistas
INV - MATCAT - Artículos de Revistas

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