Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moieties
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http://hdl.handle.net/10045/96887
| Títol: | Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moieties |
|---|---|
| Autors: | Belveren, Samet | Poyraz, Samet | Pask, Christopher M. | Ülger, Mahmut | Sansano, Jose M. | Dondas, H. Ali |
| Grups d'investigació o GITE: | Síntesis Asimétrica (SINTAS) |
| Centre, Departament o Servei: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
| Paraules clau: | Platinum complexes | Aminocarbothiol | Antibacterial | Antifungal |
| Àrees de coneixement: | Química Orgánica |
| Data de publicació: | 1-de desembre-2019 |
| Editor: | Elsevier |
| Citació bibliogràfica: | Inorganica Chimica Acta. 2019, 498: 119154. doi:10.1016/j.ica.2019.119154 |
| Resum: | Platinum complexes, derived from two families of bidentate funcionalized aroylaminocarbo-N-thyoyl prolinates, are prepared using mild conditions from prolinates, which are available via 1,3-dipolar cycloadditions. The resulting four coordinated neutral square-planar platinum(II) complexes are very stable and are fully characterized. Their structures are determined by spectroscopic and analytical methods and one of them by single crystal X-ray diffraction analysis. In this pattern, the platinum exhibits distorted square planar geometry, with cis-bond angles ranging from 89.42(2) and 94.37(6)° and trans-bond angles of 176.19(6) and 177.08(6)°, respectively. Anti(myco)bacterial and antifungal studies of all these new compounds are carried out under standardized protocols. |
| Patrocinadors: | This work is a part of Samet Belveren's ongoing PhD thesis granted by Mersin University (Project no. BAP-SBE TEB(SB) 2017-2-TP3-2564). We gratefully acknowledge financial support from Mersin University and the Spanish Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P and CTQ2014-51912-REDC), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P and CTQ2016-81797-REDC), the Generalitat Valenciana (PROMETEOII/2014/017), University of Alicante and Mersin University (Project. MEU-2017-COL-01007-M150D). |
| URI: | http://hdl.handle.net/10045/96887 |
| ISSN: | 0020-1693 (Print) | 1873-3255 (Online) |
| DOI: | 10.1016/j.ica.2019.119154 |
| Idioma: | eng |
| Tipus: | info:eu-repo/semantics/article |
| Drets: | © 2019 Elsevier B.V. |
| Revisió científica: | si |
| Versió de l'editor: | https://doi.org/10.1016/j.ica.2019.119154 |
| Apareix a la col·lecció: | INV - SINTAS - Artículos de Revistas |
Arxius per aquest ítem:
| Arxiu | Descripció | Tamany | Format | |
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 2019_Belveren_etal_InorganicaChimicaActa_final.pdf | Versión final (acceso restringido) | 1 MB | Adobe PDF | Obrir Sol·licitar una còpia |
 2019_Belveren_etal_InorganicaChimicaActa_revised.pdf | Versión revisada (acceso abierto) | 1,34 MB | Adobe PDF | Obrir Vista prèvia |
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