A Bipyridine‐Palladium Derivative as General Pre‐Catalyst for Cross‐Coupling Reactions in Deep Eutectic Solvents

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Title: A Bipyridine‐Palladium Derivative as General Pre‐Catalyst for Cross‐Coupling Reactions in Deep Eutectic Solvents
Authors: Saavedra, Beatriz | González-Gallardo, Nerea | Meli, Alessandro | Ramón, Diego J.
Research Group/s: Alternative Methodologies In Chemistry (AMIC) | Nuevos Materiales y Catalizadores (MATCAT)
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Keywords: Cross-coupling | Green chemistry | Hydrogen bonds | Ligand design | Palladium
Knowledge Area: Química Orgánica
Issue Date: 21-Aug-2019
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
Citation: Advanced Synthesis and Catalysis. 2019, 361(16): 3868-3879. doi:10.1002/adsc.201900472
Abstract: A versatile and DES‐compatible bipyridine palladium complex has been developed as a general pre‐catalyst for different cross‐coupling reactions (Hiyama, Suzuki‐Miyaura, Heck‐Mizoroki and Sonogashira) in deep eutectic solvents. Hydrogen bond capacity of the ligand allows to keep the excellent level of results previously obtained in classical organic solvents. Palladium pre‐catalyst showed a high catalytic activity for many cross‐coupling reactions, demonstrating a great versatility and applicability. Also, this methodology employs sustainable solvents as a reaction medium and highlights the potential of DES as alternative solvents in organometallic catalysis. The catalyst and DES were easily and successfully recycled. The formation of PdNPs in DES has been confirmed by TEM and XPS analysis and their role as catalyst by mercury test. The dynamic coordination of bipyridine‐type ligand in the palladium complex formation has been studied via UV/Vis.
Sponsor: This work was supported by the University of Alicante (VIGROB-316) and the Spanish Ministerio de Economia, Industria y Competitividad (CTQ2015-66624-P, PGC2018-096616-B-100). BS thanks Generalitat Valenciana (ACIF/2017/211) for a fellowship.
URI: http://hdl.handle.net/10045/95433
ISSN: 1615-4150 (Print) | 1615-4169 (Online)
DOI: 10.1002/adsc.201900472
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Peer Review: si
Publisher version: https://doi.org/10.1002/adsc.201900472
Appears in Collections:INV - AMIC - Artículos de Revistas
INV - MATCAT - Artículos de Revistas

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