Factors associated with moderate neonatal hyperthyrotropinemia

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Title: Factors associated with moderate neonatal hyperthyrotropinemia
Authors: Cortés Castell, Ernesto | Juste-Ruiz, Mercedes | Palazón Bru, Antonio | Goicoechea, Mercedes | Gil Guillén, Vicente | Rizo-Baeza, Mercedes
Research Group/s: Salud y Cuidados en Grupos Vulnerables (SACU)
Center, Department or Service: Universidad de Alicante. Departamento de Enfermería
Keywords: Thyroid-stimulating hormone (TSH) | Hypothyroidism | Neonatal hyperthyrotropinemia | Iodine nutrition status
Knowledge Area: Enfermería
Issue Date: 18-Jul-2019
Publisher: Public Library of Science (PLoS)
Citation: Cortés-Castell E, Juste M, Palazón-Bru A, Goicoechea M, Gil-Guillén VF, Rizo-Baeza MM (2019) Factors associated with moderate neonatal hyperthyrotropinemia. PLoS ONE 14(7): e0220040. https://doi.org/10.1371/journal.pone.0220040
Abstract: Background Maternal iodine deficiency is related to high neonatal thyroid-stimulating hormone (TSH) values, with the threshold of 5 mIU/L recommended as an indicator of iodine nutrition status. The objective of this study was to analyse possible risk factors for increased TSH that could distort its validity as a marker of iodine status. The clinical relevance of this research question is that if the factors associated with iodine deficiency are known, iodine supplementation can be introduced in risk groups, both during pregnancy and in newborns. Methods A case-control study was carried out in a sample of 46,622 newborns in 2002–2015 in Spain. Of these, 45,326 had a neonatal TSH value ≥5 mIU/L. The main variable was having TSH ≥5 mIU/L and the secondary variables were: sex, gestational age, day of sample extraction and maternal origin. Associated factors were analysed through a logistic regression model, calculating the odds ratio (OR). Results The factors associated with this outcome were: male sex (OR = 1.34, 95% CI: 1.20–1.50, p<0.001), originating from an Asian/Oceanic country (OR = 0.80, 95% CI: 0.54–1.20, p = 0.536) or Europe (OR = 0.80, 95% CI: 0.66–0.96, p = 0.285) (including Spain, OR = 1) [p<0.001 for America (OR = 0.54, 95% CI: 0.44–0.68) and p = 0.025 for Africa (OR = 0.78, 95% CI: 0.62–0.97)] and fewer days from birth to sampling (OR = 0.80, 95% CI: 0.77–0.82, p<0.001). Conclusions The risk of high neonatal TSH without congenital hypothyroidism is higher in males, decreases with a greater number of days from birth to extraction, and is dependent on maternal ethnicity but not on gestational age.
URI: http://hdl.handle.net/10045/94651
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0220040
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2019 Cortés-Castell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Peer Review: si
Publisher version: https://doi.org/10.1371/journal.pone.0220040
Appears in Collections:INV - SACU - Artículos de Revistas

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