Carbon Nanotubes Modified With Au for Electrochemical Detection of Prostate Specific Antigen: Effect of Au Nanoparticle Size Distribution

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Title: Carbon Nanotubes Modified With Au for Electrochemical Detection of Prostate Specific Antigen: Effect of Au Nanoparticle Size Distribution
Authors: Quintero-Jaime, Andrés Felipe | Berenguer-Murcia, Ángel | Cazorla-Amorós, Diego | Morallon, Emilia
Research Group/s: Electrocatálisis y Electroquímica de Polímeros | Materiales Carbonosos y Medio Ambiente
Center, Department or Service: Universidad de Alicante. Departamento de Química Física | Universidad de Alicante. Departamento de Química Inorgánica | Universidad de Alicante. Instituto Universitario de Materiales
Keywords: Carbon nanotubes | PSA detection | Chronoamperometry | Gold nanoparticles | Immunosensor
Knowledge Area: Química Física | Química Inorgánica
Issue Date: 27-Mar-2019
Publisher: Frontiers Media
Citation: Quintero-Jaime AF, Berenguer-Murcia Á, Cazorla-Amorós D and Morallón E (2019) Carbon Nanotubes Modified With Au for Electrochemical Detection of Prostate Specific Antigen: Effect of Au Nanoparticle Size Distribution. Front. Chem. 7:147. doi: 10.3389/fchem.2019.00147
Abstract: Different functionalized Multi-Wall Carbon Nanotube and gold nanoparticles (AuNPs) were synthesized as biosensor electrodes. These materials have been applied to the detection of the Prostate Specific Antigen (PSA). The synthesis of AuNPs was carried out using polyvinylpyrrolidone (PVP) as protecting agent. The PVP/Au molar ratio (0.5 and 50) controls the nanoparticle size distribution, obtaining a wide and narrow distribution with an average diameter of 9.5 and 6.6 nm, respectively. Nanoparticle size distribution shows an important effect in the electrochemical performance of the biosensor, increasing the electrochemical active surface area (EASA) and promoting the electron-transfer from the redox probe (Ferrocene/Ferrocenium) to the electrode. Furthermore, a narrow and small nanoparticle size distribution enhances the amount of antibodies immobilized on the transducer material and the performance during the detection of the PSA. Significant results were obtained for the quantification of PSA, with a limit of detection of 1 ng·ml−1 and sensitivities of 0.085 and 0.056 μA·mL·ng−1 for the two transducer materials in only 5 min of detection.
Sponsor: The authors would like to thank MINECO and FEDER (MAT2016-76595-R) for the financial support. AFQJ gratefully acknowledges Generalitat Valenciana for the financial support through Santiago Grisolia grant (GRISOLIA/2016/084).
URI: http://hdl.handle.net/10045/90371
ISSN: 2296-2646
DOI: 10.3389/fchem.2019.00147
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2019 Quintero-Jaime, Berenguer-Murcia, Cazorla-Amorós and Morallón. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Peer Review: si
Publisher version: https://doi.org/10.3389/fchem.2019.00147
Appears in Collections:INV - GEPE - Artículos de Revistas
INV - MCMA - Artículos de Revistas

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