Affinity of Electrochemically Deposited Sol–Gel Silica Films towards Catecholamine Neurotransmitters

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Title: Affinity of Electrochemically Deposited Sol–Gel Silica Films towards Catecholamine Neurotransmitters
Authors: Porcel-Valenzuela, María | Huerta Arráez, Francisco | Morallon, Emilia | Montilla, Francisco
Research Group/s: Electrocatálisis y Electroquímica de Polímeros
Center, Department or Service: Universidad de Alicante. Departamento de Química Física | Universidad de Alicante. Instituto Universitario de Materiales
Keywords: Electroassisted deposition | Catecholamine neurotransmitters | Liquid adsorption isotherms
Knowledge Area: Química Física
Issue Date: 19-Feb-2019
Publisher: MDPI
Citation: Porcel-Valenzuela M, Huerta F, Morallón E, Montilla F. Affinity of Electrochemically Deposited Sol–Gel Silica Films towards Catecholamine Neurotransmitters. Sensors. 2019; 19(4):868. doi:10.3390/s19040868
Abstract: Dopamine, norepinephrine, and epinephrine neurotransmitters can be detected by electrochemical oxidation in conventional electrodes. However, their similar chemical structure and electrochemical behavior makes a difficult selective analysis. In the present work, glassy carbon electrodes have been modified with silica layers, which were prepared by electroassisted deposition of sol–gel precursors. These layers were morphologically and compositionally characterized using different techniques, such as field emission scanning electron microscopy (FESEM), TEM, FTIR, or thermogravimetric analysis–mass spectrometry (TG-MS). The affinity of silica for neurotransmitters was evaluated, exclusively, by means of electrochemical methods. It was demonstrated that silica adsorbs dopamine, norepinephrine, and epinephrine, showing different interaction with silica pores. The adsorption process is dominated by a hydrogen bond between silanol groups located at the silica surface and the amine groups of neurotransmitters. Because of the different interaction with neurotransmitters, electrodes modified with silica films could be used in electrochemical sensors for the selective detection of such molecules.
Sponsor: This research was funded by the Ministerio de Ciencia, Innovación y Universidades (MAT2016-76595-R) and Conselleria de Educación, Investigación, Cultura y Deporte, Generalitat Valenciana (PROMETEO/2018/087).
URI: http://hdl.handle.net/10045/88668
ISSN: 1424-8220
DOI: 10.3390/s19040868
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Peer Review: si
Publisher version: https://doi.org/10.3390/s19040868
Appears in Collections:INV - GEPE - Artículos de Revistas

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