Study of the anti(myco)bacterial and antitumor activities of prolinate and N-amidocarbothiolprolinate derivatives based on fused tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione, bearing an indole ring
Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10045/83350
Título: | Study of the anti(myco)bacterial and antitumor activities of prolinate and N-amidocarbothiolprolinate derivatives based on fused tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione, bearing an indole ring |
---|---|
Autor/es: | Poyraz, Samet | Canacankatan, Necmiye | Belveren, Samet | Yetkin, Derya | Kibar, Kezban | Ülger, Mahmut | Sansano, Jose M. | Özcelik, Nefise Dilek | Yılmaz, Ş. Necat | Dondas, H. Ali |
Grupo/s de investigación o GITE: | Síntesis Asimétrica (SINTAS) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
Palabras clave: | Amino acids | Cycloadditions | Heterocycles | MCF-7 cells | Apoptosis | Anti(myco)bacterial |
Área/s de conocimiento: | Química Orgánica |
Fecha de publicación: | dic-2018 |
Editor: | Springer Vienna |
Cita bibliográfica: | Monatshefte für Chemie - Chemical Monthly. 2018, 149(12): 2253-2263. doi:10.1007/s00706-018-2286-8 |
Resumen: | A series of prolinate and N-amidocarbothiolprolinate derivatives based on a fused pyrrole-3,4-dione core, bearing indole ring systems, are prepared from the corresponding amino acid and an aldehyde via thermal 1,3-dipolar cycloaddition of azomethine ylides and condensation with benzoylisothiocyanate. Products are fully characterized by NMR, FT-IR, MS, and an X-ray crystal structure. The prepared compounds are screened for their antibacterial activity against a range of Gram-positive and Gram-negative bacteria and their antimycobacterial activity against M. tuberculosis H37Rv strain. In addition, two selected target compounds are evaluated for cytotoxicity, apoptosis, and anti-inflammatory effects on MCF-7 (breast carcinoma) cell lines. The incorporation of indole ring and –C(O)NHC(S)– moiety resulted to be beneficial since the biological point of view. |
Patrocinador/es: | We would like to thank Mersin University, Research Foundation (Project No: BAP 2015-AP2-1342) for financial support. |
URI: | http://hdl.handle.net/10045/83350 |
ISSN: | 0026-9247 (Print) | 1434-4475 (Online) |
DOI: | 10.1007/s00706-018-2286-8 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © Springer-Verlag GmbH Austria, part of Springer Nature 2018 |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1007/s00706-018-2286-8 |
Aparece en las colecciones: | INV - SINTAS - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2018_Poyraz_etal_MonatshefteChem_final.pdf | Versión final (acceso restringido) | 955,73 kB | Adobe PDF | Abrir Solicitar una copia |
2018_Poyraz_etal_MonatshefteChem_accepted.pdf | Accepted Manuscript (acceso abierto) | 2,01 MB | Adobe PDF | Abrir Vista previa |
Todos los documentos en RUA están protegidos por derechos de autor. Algunos derechos reservados.