Physicochemical properties and in vivo evaluation of Pt/TiO2–SiO2 nanopowders

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Title: Physicochemical properties and in vivo evaluation of Pt/TiO2–SiO2 nanopowders
Authors: López, Tessy | Ramírez, Paola | Alvarez, Daniel | Rodríguez Reinoso, Francisco | Silvestre Albero, Ana | Gómez, Esteban | Rodríguez-Castellón, Enrique
Research Group/s: Materiales Avanzados
Center, Department or Service: Universidad de Alicante. Departamento de Química Inorgánica
Keywords: Animal model | Catalytic nanomedicine | Diabetic foot | Pt/TiO2–SiO2 nanopowders | Sol–gel technique | Ultra-small platinum nanoparticles | Wounds healing
Knowledge Area: Química Inorgánica
Issue Date: 2-Oct-2018
Publisher: Future Medicine
Citation: Nanomedicine. 2018, 13(17): 2171-2185. doi:10.2217/nnm-2018-0078
Abstract: Aim: Sol–gel is a suitable and advantageous method to synthesize mixed oxide nanomaterials with unique physicochemical and biological properties. Materials & methods: In this work, TiO2–SiO2 nanopowders cogeled with platinum acetylacetonate were developed and studied in the perspective of nanomedicine. The physicochemical properties of the Pt/TiO2–SiO2 nanopowders, named NanoRa2-Pt, were evaluated in detail by means of complementary spectroscopic and microscopic tools. The nanopowder's biocatalytic efficiency in wound healing was evaluated in a Type I diabetes animal model. Results: These are TiO2–SiO2 submicron mesoporous particles with variable size and shape containing ultra-small platinum nanoparticles with catalytic properties. Conclusion: The use of NanoRa2-Pt catalyzes the natural healing processes with a faster remodeling stage. These sols, which we call nanobiocatalysts, belong to an emerging and very promising research field known as catalytic nanomedicine.
Sponsor: The authors would like to acknowledge CONACyT and Universidad Autónoma Metropolitana for the funding given to this project.
ISSN: 1743-5889 (Print) | 1748-6963 (Online)
DOI: 10.2217/nnm-2018-0078
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2018 Future Medicine Ltd
Peer Review: si
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