Using Base Rate of Low Scores to Identify Progression from Amnestic Mild Cognitive Impairment to Alzheimer's Disease

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Title: Using Base Rate of Low Scores to Identify Progression from Amnestic Mild Cognitive Impairment to Alzheimer's Disease
Authors: Oltra-Cucarella, Javier | Sánchez San Segundo, Miriam | Lipnicki, Darren M. | Sachdev, Perminder S. | Crawford, John D. | Pérez-Vicente, José A. | Cabello-Rodríguez, Luis | Ferrer-Cascales, Rosario
Research Group/s: Psicología Aplicada a la Salud y Comportamiento Humano (PSYBHE)
Center, Department or Service: Universidad de Alicante. Departamento de Psicología de la Salud
Keywords: Alzheimer’s disease | Progression | Dementia | Diagnosis | Mild cognitive impairment
Knowledge Area: Personalidad, Evaluación y Tratamiento Psicológico
Issue Date: Jul-2018
Publisher: Wiley
Citation: Journal of the American Geriatrics Society. 2018, 66(7): 1360-1366. doi:10.1111/jgs.15412
Abstract: OBJECTIVES: To investigate the implications of obtaining one or more low scores on a battery of cognitive tests on diagnosing mild cognitive impairment (MCI). DESIGN: Observational longitudinal study. SETTING: Alzheimer's Disease Neuroimaging Initiative. PARTICIPANTS: Normal controls (NC, n = 280) and participants with MCI (n = 415) according to Petersen criteria were reclassified using the Jak/Bondi criteria and number of impaired tests (NIT) criteria. MEASUREMENTS: Diagnostic statistics and hazard ratios of progression to Alzheimer's disease (AD) were compared according to diagnostic criteria. RESULTS: The NIT criteria were a better predictor of progression to AD than the Petersen or Jak/Bondi criteria, with optimal sensitivity, specificity, and positive and negative predictive value. CONCLUSION: Considering normal variability in cognitive test performance when diagnosing MCI may help identify individuals at greatest risk of progression to AD with greater certainty.
Sponsor: Data collection and sharing for this project was funded by the ADNI (National Institutes of Health Grant U01 AG024904) and Department of Defense ADNI (Award W81XWH-12–2-0012).
ISSN: 0002-8614 (Print) | 1532-5415 (Online)
DOI: 10.1111/jgs.15412
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2018, Copyright the Authors; Journal compilation © 2018, The American Geriatrics Society
Peer Review: si
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Appears in Collections:INV - PSYBHE - Artículos de Revistas

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