Facile preparation of 3-substituted 2-quinazolinones via electrogenerated base

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Title: Facile preparation of 3-substituted 2-quinazolinones via electrogenerated base
Authors: Sbei, Najwa | Batanero, Belén | Barba, Fructuoso | Haouas, Beya | Benkhoud, Mohamed Lamine | Barba, Isidoro
Research Group/s: Nuevos Materiales y Catalizadores (MATCAT)
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica
Keywords: Quinazolin-2-ones | N-heterocyclic olefins | Magnesium sacrificial anode | Electrogenerated cyanomethyl anion | Organic isocyanates
Knowledge Area: Química Orgánica
Issue Date: 19-Apr-2018
Publisher: Elsevier
Citation: Tetrahedron. 2018, 74(16): 2068-2072. doi:10.1016/j.tet.2018.03.010
Abstract: A new series of 3,4-disubstituted quinazolin-2-ones, with potential T-type calcium channel antagonist activity, and new 4-methylene-quinazolin-2-ones, promising catalysts as N-heterocyclic olefins, have been prepared in good yield by a simple reaction between 2-aminobenzophenone, or 2-aminoacetophenone, and cyanomethyl anion electrogenerated by acetonitrile reduction at a graphite electrode, followed by the addition of different organic isocyanates and subsequent heterocyclization.
Sponsor: The authors gratefully acknowledge the financial support of the University of Alcala-project Nº CCG2017/EXP-009.
URI: http://hdl.handle.net/10045/77549
ISSN: 0040-4020 (Print) | 1464-5416 (Online)
DOI: 10.1016/j.tet.2018.03.010
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2018 Elsevier Ltd.
Peer Review: si
Publisher version: https://doi.org/10.1016/j.tet.2018.03.010
Appears in Collections:INV - MATCAT - Artículos de Revistas

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