Asymmetric Organocatalytic Electrophilic Heterofunctionalization of Oxindoles
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http://hdl.handle.net/10045/76747
Title: | Asymmetric Organocatalytic Electrophilic Heterofunctionalization of Oxindoles |
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Authors: | Freckleton, Megan | Baeza, Alejandro | Benavent, Llorenç | Chinchilla, Rafael |
Research Group/s: | Nuevos Materiales y Catalizadores (MATCAT) | Catálisis Estereoselectiva en Síntesis Orgánica (CESO) |
Center, Department or Service: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
Keywords: | Asymmetric catalysis | Heterocycles | Heterofunctionalization | Organocatalysis | Quaternary stereocenters |
Knowledge Area: | Química Orgánica |
Issue Date: | Jun-2018 |
Publisher: | Wiley-VCH Verlag GmbH & Co. KGaA |
Citation: | Asian Journal of Organic Chemistry. 2018, 7(6): 1006-1014. doi:10.1002/ajoc.201800146 |
Abstract: | The asymmetric synthesis of 3‐substituted oxindoles is a topic of considerable importance because these functionalized heterocycles are found in many natural products and drugs. In the last decade, significant advances have been made towards the asymmetric synthesis of 3‐heteroatom‐substituted oxindoles as a result of major improvements in asymmetric organocatalysis. This review will focus on the different types of asymmetric electrophilic organocatalyzed reactions, including the amination, halogenation, hydroxylation, and sulfenylation of oxindoles to form their enantioenriched 3‐heterosubstituted derivatives. |
Sponsor: | We thank the Spanish Ministerio de Economía, Industria y Competitividad (CTQ2015-66624-P) and the University of Alicante (VIGROB-173, VIGROB-285, UAUSTI17-06, UADIF17-27) for the financial support. M.F. thanks the University of Edinburgh for an ERASMUS fellowship. |
URI: | http://hdl.handle.net/10045/76747 |
ISSN: | 2193-5807 (Print) | 2193-5815 (Online) |
DOI: | 10.1002/ajoc.201800146 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Rights: | © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim |
Peer Review: | si |
Publisher version: | https://doi.org/10.1002/ajoc.201800146 |
Appears in Collections: | INV - MATCAT - Artículos de Revistas INV - CESO - Artículos de Revistas INV - AMIC - Artículos de Revistas |
Files in This Item:
File | Description | Size | Format | |
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2018_Freckleton_etal_AsianJOrgChem_final.pdf | Versión final (acceso restringido) | 2,29 MB | Adobe PDF | Open Request a copy |
2018_Freckleton_etal_AsianJOrgChem_accepted.pdf | Accepted Manuscript (acceso abierto) | 1,87 MB | Adobe PDF | Open Preview |
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