The use of an antioxidant dressing on hard-to-heal wounds: a multicentre, prospective case series

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Title: The use of an antioxidant dressing on hard-to-heal wounds: a multicentre, prospective case series
Authors: Castro, Begoña | Bastida, Félix D. | Segovia Gómez, Teresa | López Casanova, Pablo | Soldevilla Agreda, J. Javier | Verdú, José
Research Group/s: Grupo Balmis de Investigación en Salud Comunitaria e Historia de la Ciencia
Center, Department or Service: Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia
Keywords: Antioxidant dressing | Wound healing | Hard-to-heal wounds | Oxidative stress | Moist wound care
Knowledge Area: Enfermería
Issue Date: 15-Dec-2017
Publisher: Mark Allen Healthcare
Citation: Journal of Wound Care. 2017, 26(12): 742-750. doi:10.12968/jowc.2017.26.12.742
Abstract: Objective: Oxidative stress can contribute to impaired wound healing and chronic wounds. Our objective was to test the results of a new antioxidant dressing that could help stop the oxidative stress of cells in the wound bed. Method: A multicentre, prospective case study series was conducted in three Spanish hospitals. The RESVECH 2.0 index was used for healing assessment. Data from each patient was collected by the attending clinical researchers. Data analysis was performed using the statistical concept intention-to-treat (ITT). Descriptive results were presented as frequency and percentages for qualitative variables and mean, standard deviation (SD), range and median for quantitative variables. For analytical-inferential analyses, incidence of healing was calculated for chronic and acute wounds. Relative risk (RR) was used to establish the differences of healing between both types of wounds. Healing was represented by Kaplan-Meier survival curves, and these were compared using the log-rank test. Results: A total of 31 patients with hard-to-heal wounds were recruited. During the 8-week follow-up period, nine wounds (29%) completely healed, of which seven (77.8%) were acute and two (22.2%) chronic. The remaining wounds (22) showed a significant improvement after treatment with the antioxidant dressing. RESVECH 2.0 scores decreased an average of 10.16 points over the 8-week period. Conclusion: The antioxidant dressing could represent an alternative in the dressing landscape for many types of acute and chronic wounds.
Sponsor: Partial funding for this project was provided by the Basque Government Department of Economic Development and Competitiveness (Spain) and the European Regional Development Fund under the program GAITEK. Additional funds were also obtained from the Spanish Centre for Development of Industrial Technology (CDTI).
URI: http://hdl.handle.net/10045/74476
ISSN: 0969-0700 (Print) | 2052-2916 (Online)
DOI: 10.12968/jowc.2017.26.12.742
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2017 MA Healthcare Limited
Peer Review: si
Publisher version: https://doi.org/10.12968/jowc.2017.26.12.742
Appears in Collections:INV - BISCHA - Artículos de Revistas

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