An efficient catalytic method for the synthesis of pyrido[2,3-d]pyrimidines as biologically drug candidates by using novel magnetic nanoparticles as a reusable catalyst

Abstract

A convenient method for the synthesis of pyrido[2,3-d]pyrimidines by using the novel nano-magnetic silica-bonded S-sulfonic acid[Fe3O4@SiO2@(CH2)3S–SO3H] as an efficient and recyclable catalyst under neat conditions is described. The major advantages of the present methodology are high yield, short reaction time, and reusability of the catalyst. Furthermore, the nano-magnetic silica-bonded S-sulfonic acid was fully characterized by using various techniques such as FT-IR, TG/DTG, DTA, EDX, μXRF, XRD, HRTEM, SEM, SEM elemental mapping, XPS, and N2 physisorption. The results obtained from this research support the idea of rational design, synthesis, and applications of task-specific and reusable catalysts for the preparation of various polynitrogenated heterocyclic compounds containing 1,4-dihydropyridine moieties.