An efficient catalytic method for the synthesis of pyrido[2,3-d]pyrimidines as biologically drug candidates by using novel magnetic nanoparticles as a reusable catalyst

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Title: An efficient catalytic method for the synthesis of pyrido[2,3-d]pyrimidines as biologically drug candidates by using novel magnetic nanoparticles as a reusable catalyst
Authors: Moradi, Saeid | Zolfigol, Mohammad Ali | Zarei, Mahmoud | Alonso, Diego A. | Khoshnood, Abbas | Tajally, Aria
Research Group/s: Catálisis Estereoselectiva en Síntesis Orgánica (CESO)
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Keywords: 1,4‐dihydropyridines | Nano‐magnetic silica‐bonded S‐sulfonic acid | Neat conditions | Nitrogen heterocyclic compounds | Pyrido[2,3‐d]pyrimidines | Reusable catalyst | Task‐specific catalyst
Knowledge Area: Química Orgánica
Issue Date: Feb-2018
Publisher: John Wiley & Sons
Citation: Applied Organometallic Chemistry. 2018, 32(2): e4043. doi:10.1002/aoc.4043
Abstract: A convenient method for the synthesis of pyrido[2,3-d]pyrimidines by using the novel nano-magnetic silica-bonded S-sulfonic acid[Fe3O4@SiO2@(CH2)3S–SO3H] as an efficient and recyclable catalyst under neat conditions is described. The major advantages of the present methodology are high yield, short reaction time, and reusability of the catalyst. Furthermore, the nano-magnetic silica-bonded S-sulfonic acid was fully characterized by using various techniques such as FT-IR, TG/DTG, DTA, EDX, μXRF, XRD, HRTEM, SEM, SEM elemental mapping, XPS, and N2 physisorption. The results obtained from this research support the idea of rational design, synthesis, and applications of task-specific and reusable catalysts for the preparation of various polynitrogenated heterocyclic compounds containing 1,4-dihydropyridine moieties.
Sponsor: We thank Bu‐Ali Sina University, Iran National Science Foundation (INSF) (Grant Number: 940124), National Elites Foundation, University of Alicante (VIGROB‐173, UAUSTI16‐03), and the Spanish Ministerio de Economía y Competitividad (CTQ2015‐66624‐P) for financial support to our research groups.
URI: http://hdl.handle.net/10045/73199
ISSN: 0268-2605 (Print) | 1099-0739 (Online)
DOI: 10.1002/aoc.4043
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2017 John Wiley & Sons, Ltd.
Peer Review: si
Publisher version: http://dx.doi.org/10.1002/aoc.4043
Appears in Collections:INV - CESO - Artículos de Revistas

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