Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study

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Title: Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study
Authors: Delgado-García, Silvia | Martínez-Escoriza, Juan-Carlos | Alba, Alfonso | Martín-Bayón, Tina-Aurora | Ballester-Galiana, Hortensia | Peiró, Gloria | Caballero, Pablo | Ponce-Lorenzo, Jose
Research Group/s: Grupo Balmis de Investigación en Salud Comunitaria e Historia de la Ciencia
Center, Department or Service: Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia
Keywords: Breast cancer | Human papillomavirus | Prevalence | PCR
Knowledge Area: Enfermería
Issue Date: 8-May-2017
Publisher: BioMed Central
Citation: BMC Cancer. 2017, 17:320. doi:10.1186/s12885-017-3308-3
Abstract: Background: Breast cancer is one of the most important neoplasia among women. It was recently suggested that biological agents could be the etiological cause, particularly Human Papilloma Virus (HPV). The aim of this study was to explore the presence of HPV DNA in a case-control study. Methods: We performed our study including 251 cases (breast cancer) and 186 controls (benign breast tumors), using three different molecular techniques with PCR (GP5/GP6, CLART® and DIRECT FLOW CHIP®). Results: HPV DNA was evidenced in 51.8% of the cases and in 26.3% of the controls (p < 0.001). HPV-16 was the most prevalent serotype. The odds ratio (OR) of HPV within a multivariate model, taking into account age and breastfeeding, was 4.034. Conclusions: Our study, with methodological rigour and a sample size not previously found in the literature, demonstrate a significant presence of HPV DNA in breast cancer samples. A possible causal relationship, or mediation or not as a cofactor, remains to be established by future studies.
ISSN: 1471-2407
DOI: 10.1186/s12885-017-3308-3
Language: eng
Type: info:eu-repo/semantics/article
Rights: © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Peer Review: si
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