A stretchable and screen-printed electrochemical sensor for glucose determination in human perspiration
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Título: | A stretchable and screen-printed electrochemical sensor for glucose determination in human perspiration |
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Autor/es: | Abellán-Llobregat, Alejandra | Jeerapan, Itthipon | Bandodkar, Amay | Vidal, Lorena | Canals, Antonio | Wang, Joe | Morallon, Emilia |
Grupo/s de investigación o GITE: | Espectroscopía Atómica-Masas y Química Analítica en Condiciones Extremas | Electrocatálisis y Electroquímica de Polímeros |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Analítica, Nutrición y Bromatología | Universidad de Alicante. Departamento de Química Física | Universidad de Alicante. Instituto Universitario de Materiales |
Palabras clave: | Glucose biosensor | Printed electronics | Stretchable device | H2O2 | Catalyst | Perspiration |
Área/s de conocimiento: | Nutrición y Bromatología | Química Analítica | Química Física |
Fecha de publicación: | 15-may-2017 |
Editor: | Elsevier |
Cita bibliográfica: | Biosensors and Bioelectronics. 2017, 91: 885-891. doi:10.1016/j.bios.2017.01.058 |
Resumen: | Here we present two types of all-printable, highly stretchable, and inexpensive devices based on platinum (Pt)-decorated graphite for glucose determination in physiological fluids. Said devices are: a non-enzymatic sensor and an enzymatic biosensor, the latter showing promising results. Glucose has been quantified by measuring hydrogen peroxide (H2O2) reduction by chronoamperometry at −0.35 V (vs pseudo-Ag/AgCl) using glucose oxidase immobilized on Pt-decorated graphite. The sensor performs well for the quantification of glucose in phosphate buffer solution (0.25 M PBS, pH 7.0), with a linear range between 0 mM and 0.9 mM, high sensitivity and selectivity, and a low limit of detection (LOD). Thus, it provides an alternative non-invasive and on-body quantification of glucose levels in human perspiration. This biosensor has been successfully applied on real human perspiration samples and results also show a significant correlation between glucose concentration in perspiration and glucose concentration in blood measured by a commercial glucose meter. |
Patrocinador/es: | This work is supported by the Generalitat Valenciana (Prometeo2013/038), by the Ministerio de Economia y Competitividad (MAT2016-76595-R), and the U.S. National Institute of Biomedical Imaging and Bioengineering of NIH (R21EB019698). A. Abellán also thanks the Generalitat Valenciana for her fellowship and the Universidad de Alicante for her fellowship for a research stay in University of San Diego, California. |
URI: | http://hdl.handle.net/10045/65156 |
ISSN: | 0956-5663 (Print) | 0956-5663 (Online) |
DOI: | 10.1016/j.bios.2017.01.058 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2017 Elsevier B.V. |
Revisión científica: | si |
Versión del editor: | http://dx.doi.org/10.1016/j.bios.2017.01.058 |
Aparece en las colecciones: | INV - SP-BG - Artículos de Revistas INV - GEPE - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
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2017_Abellan-Llobregat_etal_BIOS_final.pdf | Versión final (acceso restringido) | 588,25 kB | Adobe PDF | Abrir Solicitar una copia |
2017_Abellan-Llobregat_etal_BIOS_preprint.pdf | Preprint (acceso abierto) | 1,65 MB | Adobe PDF | Abrir Vista previa |
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