Understanding How the Diagnostic Delay of Spondyloarthritis Differs Between Women and Men: A Systematic Review and Metaanalysis

Empreu sempre aquest identificador per citar o enllaçar aquest ítem http://hdl.handle.net/10045/63569
Información del item - Informació de l'item - Item information
Títol: Understanding How the Diagnostic Delay of Spondyloarthritis Differs Between Women and Men: A Systematic Review and Metaanalysis
Autors: Jovaní, Vega | Blasco-Blasco, Mar | Ruiz-Cantero, María Teresa | Pascual, Eliseo
Grups d'investigació o GITE: Salud Pública
Centre, Departament o Servei: Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia
Paraules clau: Spondyloarthritis | Sex differences | Sex bias | Diagnostic delay
Àrees de coneixement: Medicina Preventiva y Salud Pública
Data de publicació: 1-de febrer-2017
Editor: The Journal of Rheumatology Publishing Company Limited
Citació bibliogràfica: The Journal of Rheumatology. 2017, 44(2): 174-183. doi:10.3899/jrheum.160825
Resum: Objective. To identify empirical evidence of diagnostic delay in spondyloarthritis (SpA), determine whether sex-related differences persist, and conduct an analysis from that perspective of the possible causes, including the influence of quality research, in this group of inflammatory rheumatic diseases. Methods. A systematic review was done of delay in diagnosis of SpA in MEDLINE and EMBASE and other sources. Study quality was determined in line with the Strengthening The Reporting of OBservational studies in Epidemiology (STROBE) statement. A metaanalysis of 13 papers reporting sex-disaggregated data was performed to evaluate sex-related differences in diagnostic delay. The global effect of diagnostic delay by sex was calculated using means difference (D) through a fixed effects model. Results. The review included 23,883 patients (32.3% women) from 42 papers. No significant differences between the sexes were detected for symptoms at disease onset or during evolution. However, the mean for delay in diagnosis of SpA showed sex-related differences, being 8.8 years (7.4–10.1) for women and 6.5 (5.6–7.4) for men (p = 0.01). Only 40% of papers had high quality. A metaanalysis included 12,073 participants (31.2% women). The mean global effect was D = 0.6 years (0.31–0.89), indicating that men were diagnosed 0.6 year (7 months) before women. Conclusion. Delay in diagnosis of SpA persists, and is longer in women than in men. There are no significant sex-related differences in symptoms that could explain sex-related differences in diagnostic delay. Methodological and possible publication bias could result in sex-biased medical practice.
Patrocinadors: Supported by FEDER-Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Spain (grant PI11/00865).
URI: http://hdl.handle.net/10045/63569
ISSN: 0315-162X (Print) | 1499-2752 (Online)
DOI: 10.3899/jrheum.160825
Idioma: eng
Tipus: info:eu-repo/semantics/article
Drets: © 2017 by The Journal of Rheumatology Publishing Company Limited
Revisió científica: si
Versió de l'editor: http://dx.doi.org/10.3899/jrheum.160825
Apareix a la col·lecció: INV - SP - Artículos de Revistas

Arxius per aquest ítem:
Arxius per aquest ítem:
Arxiu Descripció Tamany Format  
Thumbnail2017_Jovani_eta_JRheumat_rev.pdfVersión revisada (acceso abierto)610,54 kBAdobe PDFObrir Vista prèvia

Tots els documents dipositats a RUA estan protegits per drets d'autors. Alguns drets reservats.