Impact of prematurity and immigration on neonatal screening for sickle cell disease

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Title: Impact of prematurity and immigration on neonatal screening for sickle cell disease
Authors: Cortés Castell, Ernesto | Palazón Bru, Antonio | Pla, Carolina | Goicoechea, Mercedes | Rizo-Baeza, Mercedes | Juste-Ruiz, Mercedes | Gil Guillén, Vicente
Research Group/s: Salud y Cuidados en Grupos Vulnerables (SACU)
Center, Department or Service: Universidad de Alicante. Departamento de Enfermería
Keywords: Prematurity | Immigration | Neonatal screening | Sickle cell disease
Knowledge Area: Enfermería
Issue Date: 7-Feb-2017
Publisher: Public Library of Science (PLoS)
Citation: Cortés-Castell E, Palazón-Bru A, Pla C, Goicoechea M, Rizo-Baeza MM, Juste M, et al. (2017) Impact of prematurity and immigration on neonatal screening for sickle cell disease. PLoS ONE 12(2): e0171604. doi:10.1371/journal.pone.0171604
Abstract: Background: Others have described a relationship between hemoglobin A levels and gestational age, gender and ethnicity. However, studies are needed to determine normal cut-off points considering these factors. To address this issue we designed a study to determine the percentiles of normality of neonatal hemoglobin A levels taking these factors into account. Methods: This cross-sectional study involved 16,025 samples for sickle cell disease screening in the province of Alicante, Spain, which has a high immigration rate. The primary variable was hemoglobin A, and the secondary variables were gender, gestational age (preterm and full term) and maternal origin (Spain, the rest of Europe, North Africa, Sub-Saharan Africa, Latin America and Asia). Percentiles of normality (1 and 99) were obtained by origin, gender and gestational age using quantile regression models and bootstrap samples. The association between these percentiles of normality and altered levels (≥1%) of hemoglobin E was analyzed. We obtained the percentiles of normality (1 and 99) for each maternal origin, gender and gestational age. Results: Of a total of 88 possible E carriers, 65 had above-normal hemoglobin A levels (74%). The levels of normality for hemoglobin A varied greatly according to the maternal origin and gestational age. Conclusion: With the levels of normality that we established it is possible to discard samples with unrecorded blood transfusions. Our methodology could be applied to other diseases in the neonatal screening.
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0171604
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2017 Cortés-Castell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Peer Review: si
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Appears in Collections:INV - SACU - Artículos de Revistas

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