TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model
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Campo DC | Valor | Idioma |
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dc.contributor | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) | es_ES |
dc.contributor.author | Prieto, Daniel | - |
dc.contributor.author | Carpena, Núria | - |
dc.contributor.author | Maneu, Victoria | - |
dc.contributor.author | Gil, María Luisa | - |
dc.contributor.author | Pla, Jesús | - |
dc.contributor.author | Gozalbo, Daniel | - |
dc.contributor.other | Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía | es_ES |
dc.date.accessioned | 2017-02-08T12:05:21Z | - |
dc.date.available | 2017-02-08T12:05:21Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.citation | Microbes and Infection. 2016, 18(10): 656-660. doi:10.1016/j.micinf.2016.05.005 | es_ES |
dc.identifier.issn | 1286-4579 (Print) | - |
dc.identifier.issn | 1769-714X (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/62750 | - |
dc.description.abstract | Invasive candidiasis often arises from translocation of endogenous yeasts from the gastrointestinal tract to the bloodstream. Here we describe that both wild type and TLR2−/− mice strains, orally administered with Candida albicans yeasts, display similar sustained high level of gut colonization when oral antibacterial treatment is present, while removal of antibiotic treatment causes a progressive clearance of yeasts in control but not in TLR2−/− mice. Fungal invasion of internal organs, following immunosuppression of colonized mice, was increased in TLR2−/− mice. These results point out to a role of TLR2 in gut protection against colonization and endogenous invasion by C. albicans. | es_ES |
dc.description.sponsorship | This work was supported by grant PI080556 (Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Spain) and BIO2012-31839 (Ministerio de Ciencia e Innovación, Spain). | es_ES |
dc.language | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | © 2016 Institut Pasteur. Published by Elsevier Masson SAS. | es_ES |
dc.subject | Candida albicans | es_ES |
dc.subject | Gut colonization | es_ES |
dc.subject | TLR2 | es_ES |
dc.subject | Immunosuppressed mice | es_ES |
dc.subject.other | Farmacología | es_ES |
dc.title | TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.peerreviewed | si | es_ES |
dc.identifier.doi | 10.1016/j.micinf.2016.05.005 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.micinf.2016.05.005 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | es_ES |
Aparece en las colecciones: | INV - NEUROVIS - Artículos de Revistas |
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2016_Prieto_etal_MicrobInf_final.pdf | Versión final (acceso restringido) | 378,02 kB | Adobe PDF | Abrir Solicitar una copia |
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