TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model

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Title: TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model
Authors: Prieto, Daniel | Carpena, Núria | Maneu, Victoria | Gil, María Luisa | Pla, Jesús | Gozalbo, Daniel
Research Group/s: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)
Center, Department or Service: Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía
Keywords: Candida albicans | Gut colonization | TLR2 | Immunosuppressed mice
Knowledge Area: Farmacología
Issue Date: Oct-2016
Publisher: Elsevier
Citation: Microbes and Infection. 2016, 18(10): 656-660. doi:10.1016/j.micinf.2016.05.005
Abstract: Invasive candidiasis often arises from translocation of endogenous yeasts from the gastrointestinal tract to the bloodstream. Here we describe that both wild type and TLR2−/− mice strains, orally administered with Candida albicans yeasts, display similar sustained high level of gut colonization when oral antibacterial treatment is present, while removal of antibiotic treatment causes a progressive clearance of yeasts in control but not in TLR2−/− mice. Fungal invasion of internal organs, following immunosuppression of colonized mice, was increased in TLR2−/− mice. These results point out to a role of TLR2 in gut protection against colonization and endogenous invasion by C. albicans.
Sponsor: This work was supported by grant PI080556 (Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Spain) and BIO2012-31839 (Ministerio de Ciencia e Innovación, Spain).
ISSN: 1286-4579 (Print) | 1769-714X (Online)
DOI: 10.1016/j.micinf.2016.05.005
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2016 Institut Pasteur. Published by Elsevier Masson SAS.
Peer Review: si
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Appears in Collections:INV - NEUROVIS - Artículos de Revistas

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