On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals
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Título: | On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals |
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Autor/es: | Mojica, Francisco J.M. | Montoliu, Lluis |
Grupo/s de investigación o GITE: | Microbiología Molecular |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología |
Palabras clave: | CRISPR | CRISPR-Cas | Key events | Milestones |
Área/s de conocimiento: | Microbiología |
Fecha de publicación: | oct-2016 |
Editor: | Elsevier |
Cita bibliográfica: | Trends in Microbiology. 2016, 24(10): 811-820. doi:10.1016/j.tim.2016.06.005 |
Resumen: | Clustered regularly-interspaced short palindromic repeat (CRISPR) sequences cooperate with CRISPR-associated (Cas) proteins to form the basis of CRISPR-Cas adaptive immune systems in prokaryotes. For more than 20 years, these systems were of interest only to specialists, mainly molecular microbiologists, who tried to understand the properties of this unique defense mechanism. In 2012, the potential of CRISPR-Cas systems was uncovered and these were presented as genome-editing tools with an outstanding capacity to trigger targeted genetic modifications that can be applied to virtually any organism. Shortly thereafter, in early 2013, these tools were shown to efficiently drive specific modification of mammalian genomes. This review attempts to summarize, in a comprehensive manner, the key events and milestones that brought CRISPR-Cas technology from prokaryotes to mammals. |
Patrocinador/es: | CRISPR-Cas research in FJMM and LM laboratories is funded through the Spanish Ministry of Economy and Competitiveness (MINECO) [BIO2012-39980 and BIO2015-70978-R] to LM, and [BIO2014-53029-P] to FJMM; the Centre for Networked Biomedical Research on Rare Diseases (CIBERER-ISCIII) [ACCI 2015] to LM, and the Biomedical and Biological Sciences (BMBS) European Cooperation in Science and Technology (COST) action [BM1308 SALAAM] to LM. |
URI: | http://hdl.handle.net/10045/61952 |
ISSN: | 0966-842X (Print) | 1878-4380 (Online) |
DOI: | 10.1016/j.tim.2016.06.005 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2016 Elsevier Ltd. |
Revisión científica: | si |
Versión del editor: | http://dx.doi.org/10.1016/j.tim.2016.06.005 |
Aparece en las colecciones: | INV - Microbiología Molecular - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
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2016_Mojica_Montoliu_TrendsMicrobiol_final.pdf | Versión final (acceso restringido) | 1,51 MB | Adobe PDF | Abrir Solicitar una copia |
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