Electrochemical detection of cytosine and 5-methylcytosine on Au(111) surfaces
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http://hdl.handle.net/10045/53445
Títol: | Electrochemical detection of cytosine and 5-methylcytosine on Au(111) surfaces |
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Autors: | Brotons Cuevas, Ariadna | Arán-Ais, Rosa M. | Feliu, Juan M. | Montiel, Vicente | Iniesta, Jesus | Vidal-Iglesias, Francisco J. | Solla-Gullón, José |
Grups d'investigació o GITE: | Electroquímica Aplicada y Electrocatálisis | Electroquímica de Superficies |
Centre, Departament o Servei: | Universidad de Alicante. Departamento de Química Física | Universidad de Alicante. Instituto Universitario de Electroquímica |
Paraules clau: | Cytosine | 5-Methylcytosine | Au(111) | Sensor | Electrochemistry |
Àrees de coneixement: | Química Física |
Data de publicació: | d’abril-2016 |
Editor: | Elsevier |
Citació bibliogràfica: | Electrochemistry Communications. 2016, 65: 27-30. doi:10.1016/j.elecom.2016.02.008 |
Resum: | In this communication we report a voltammetric study of the adsorption–desorption of cytosine (C) and methylcytosine (mC) on well-defined gold (Au) electrodes. The voltammetric measurements clearly indicate that these processes are extremely sensitive to the Au surface structure and in particular to the presence of (111) surface domains. Interestingly, on Au(111) surfaces, a linear correlation between the C and mC concentrations (logarithm scale) and the peak potential of the main voltammetric feature is found. In addition, in the simultaneous presence of both molecules, mC governs the electrochemical response, which has allowed its accurate quantification in C-mC mixtures. In situ FTIR spectroscopic measurements have been carried out to deepen on this mC electrochemical sensitivity. This research may contribute to the future development of an electrochemical sensor for the determination of the degree of methylation in DNA. |
Patrocinadors: | This work has been financially supported by the MINECO through projects CTQ2013-48280-C3-3-R, CTQ2013-44083-P and by the Generalitat Valenciana through project PROMETEOII/2014/013. |
URI: | http://hdl.handle.net/10045/53445 |
ISSN: | 1388-2481 (Print) | 1873-1902 (Online) |
DOI: | 10.1016/j.elecom.2016.02.008 |
Idioma: | eng |
Tipus: | info:eu-repo/semantics/article |
Drets: | © 2016 Elsevier B.V. |
Revisió científica: | si |
Versió de l'editor: | http://dx.doi.org/10.1016/j.elecom.2016.02.008 |
Apareix a la col·lecció: | INV - EQSUP - Artículos de Revistas INV - LEQA - Artículos de Revistas |
Arxius per aquest ítem:
Arxiu | Descripció | Tamany | Format | |
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2016_Brotons_etal_ElectrComm_final.pdf | Versión final (acceso restringido) | 768,63 kB | Adobe PDF | Obrir Sol·licitar una còpia |
2016_Brotons_etal_ElectrComm_accepted.pdf | Accepted Manuscript (acceso abierto) | 480,54 kB | Adobe PDF | Obrir Vista prèvia |
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