Carbon materials for the electrooxidation of nucleobases, nucleosides and nucleotides toward cytosine methylation detection: a review

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Title: Carbon materials for the electrooxidation of nucleobases, nucleosides and nucleotides toward cytosine methylation detection: a review
Authors: Brotons Cuevas, Ariadna | Vidal-Iglesias, Francisco J. | Solla-Gullón, José | Iniesta, Jesus
Research Group/s: Electroquímica Aplicada y Electrocatálisis | Electroquímica de Superficies
Center, Department or Service: Universidad de Alicante. Departamento de Química Física | Universidad de Alicante. Instituto Universitario de Electroquímica
Keywords: Carbon materials | Electrooxidation | Nucleobases | Nucleosides | Nucleotides | Cytosine methylation detection
Knowledge Area: Química Física
Issue Date: 2016
Publisher: Royal Society of Chemistry
Citation: Analytical Methods. 2016, 8: 702-715. doi:10.1039/C5AY02616D
Abstract: Improved analytical methods for the determination of the degree of methylation of DNA are of vital relevance, as they may enable the detection of certain diseases, such as carcinomas and infertility, in the early stages of development. Among the analytical methods for the detection and quantification of epigenetic modifications in DNA, electroanalytical platforms are emerging as potential feasible tools for clinical purposes. This review describes the fundamentals of the electrochemical responses of nucleobases, nucleosides, nucleotides and DNA in general from the pioneering studies at mercury electrodes to the most recent studies during the last two decades. Concerning these latter studies, we will exclusively focus on carbonaceous electrodes such as carbon, graphite, glassy carbon, boron-doped diamond, carbon nanofibers, carbon nanotubes and graphene. This review will also provide an overview of the feasibility of the development of electrochemical sensors for the simultaneous determination and quantification of naturally occurring DNA bases and nucleotides as well as the methylation of cytosine in DNA using carbon materials.
Sponsor: The authors give thanks to the University of Alicante for funding and collaboration in this review. This work has also been financially supported by the MICINN-FEDER (Spain) through the projects CTQ2013-48280-C3-3 R and CTQ2013-44083-P.
ISSN: 1759-9660 (Print) | 1759-9679 (Online)
DOI: 10.1039/C5AY02616D
Language: eng
Type: info:eu-repo/semantics/article
Rights: © Royal Society of Chemistry 2016
Peer Review: si
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