On the Specific Adsorption of 7-methylguanine on Au(111) Surfaces for the Electroanalytical Sensing of Methylation Levels

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Title: On the Specific Adsorption of 7-methylguanine on Au(111) Surfaces for the Electroanalytical Sensing of Methylation Levels
Authors: Brotons Cuevas, Ariadna | Feliu, Juan M. | Montiel, Vicente | Iniesta, Jesus | Vidal-Iglesias, Francisco J. | Solla-Gullón, José
Research Group/s: Electroquímica Aplicada y Electrocatálisis | Electroquímica de Superficies
Center, Department or Service: Universidad de Alicante. Departamento de Química Física | Universidad de Alicante. Instituto Universitario de Electroquímica
Keywords: Gas chromatography | Liquid chromatography | Analytical methods
Knowledge Area: Química Física
Issue Date: 4-Nov-2015
Publisher: iMedPub
Citation: Insights in Analytical Electrochemistry. 2015, 1(1): 7
Abstract: The electrochemical determination of 7-methylguanine (7-mG) may result of interest because its presence can serve as probe of cytosine methylation of which is known as the most relevant epigenetic modification of DNA. This work explores the electrochemical response of 7-mG on different gold surfaces, both poly and single crystalline surfaces (Au (110), Au (111) and Au (100)). The results show that the adsorption-desorption process of the 7-mG is sensitive to the surface structure of the gold electrodes. Particularly, 7-mG adsorption-desorption profile on a Au (111) electrode exhibits some specific contributions which are found sensitive to the 7-mG concentration and, thereby could allow its quantification. These results may shed light on the future development of an electrochemical sensor for the diagnosis of the methylation degree in DNA.
Sponsor: Authors would like to acknowledge funding obtained through the Spanish Ministry of Science and Innovation (MICINN) CTQ2013-48280-C3-3-R project.
URI: http://hdl.handle.net/10045/52417
ISSN: 2470-9867
Language: eng
Type: info:eu-repo/semantics/article
Rights: © Copyright iMedPub. Licensed under a Creative Commons Attribution License
Peer Review: si
Publisher version: http://electroanalytical.imedpub.com/archive.php
Appears in Collections:INV - EQSUP - Artículos de Revistas
INV - LEQA - Artículos de Revistas

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