Highest Plasma Phenylalanine Levels in (Very) Premature Infants on Intravenous Feeding; A Need for Concern

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dc.contributorSalud y Cuidados en Grupos Vulnerables (SACU)es
dc.contributorEnfermería y Cultura de los Cuidadoses
dc.contributor.authorCortés Castell, Ernesto-
dc.contributor.authorSánchez-González, Pablo-
dc.contributor.authorPalazón Bru, Antonio-
dc.contributor.authorBosch-Giménez, Vicente-
dc.contributor.authorManero, Herminia-
dc.contributor.authorJuste-Ruiz, Mercedes-
dc.contributor.authorRizo-Baeza, Mercedes-
dc.contributor.authorGil Guillén, Vicente-
dc.contributor.otherUniversidad de Alicante. Departamento de Enfermeríaes
dc.identifier.citationCortés-Castell E, Sánchez-González P, Palazón-Bru A, Bosch-Giménez V, Manero-Soler H, Juste-Ruiz M, et al. (2015) Highest Plasma Phenylalanine Levels in (Very) Premature Infants on Intravenous Feeding; A Need for Concern. PLoS ONE 10(9): e0138532. doi:10.1371/journal.pone.0138532es
dc.description.abstractObjective. To analyse the association in newborns between blood levels of phenylalanine and feeding method and gestational age. Study Design. This observational, cross-sectional study included a sample of 11,829 infants between 2008 and 2013 in a Spanish region. Data were recorded on phenylalanine values, feeding method [breast, formula, mixed (breast plus formula), or partial or fully intravenous feeding], gestational age in weeks (<32, 32–37, ≥37), gender and days since birth at the moment of blood collection. Outcomes were [phenylalanine] and [phenylalanine] ≥95th percentile. Associations were analysed using multivariate models [linear (means difference) and logistic regression (adjusted odds ratios)]. Results. Higher phenylalanine values were associated with lower gestational age (p<0.001) and with intravenous feeding (p<0.001). Conclusion. The degree of prematurity and intravenous feeding influenced the plasma concentration of phenylalanine in the newborn. Caution should be taken in [phenylalanine] for newborns with intravenous feeding, monitoring them carefully. Very preterm infants given the recommended amount of amino acids should also be strictly monitored. These findings should be taken into consideration and call for adapting the amounts to the needs of the infant.es
dc.publisherPublic Library of Science (PLoS)es
dc.rights© 2015 Cortés-Castell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedes
dc.subjectBlood levelses
dc.subjectIntravenous feedinges
dc.subjectPremature infantses
dc.titleHighest Plasma Phenylalanine Levels in (Very) Premature Infants on Intravenous Feeding; A Need for Concernes
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