Neuroprotective Effect of Tauroursodeoxycholic Acid on N-Methyl-D-Aspartate-Induced Retinal Ganglion Cell Degeneration

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Title: Neuroprotective Effect of Tauroursodeoxycholic Acid on N-Methyl-D-Aspartate-Induced Retinal Ganglion Cell Degeneration
Authors: Gómez-Vicente, Violeta | Lax, Pedro | Fernández Sánchez, Laura | Rondón, Netxibeth | Esquiva Sobrino, Gema | Germain Martínez, Francisco | Villa Polo, Pedro de la | Cuenca, Nicolás
Research Group/s: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)
Center, Department or Service: Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología
Keywords: Retinal ganglion cell degeneration | Tauroursodeoxycholic acid | N-methyl-D-aspartate (NMDA)-induced | Neuroprotective effect
Knowledge Area: Biología Celular | Fisiología | Anatomía y Embriología Humana
Issue Date: 17-Sep-2015
Publisher: Public Library of Science (PLoS)
Citation: Gómez-Vicente V, Lax P, Fernández-Sánchez L, Rondón N, Esquiva G, Germain F, et al. (2015) Neuroprotective Effect of Tauroursodeoxycholic Acid on N-Methyl-D-Aspartate-Induced Retinal Ganglion Cell Degeneration. PLoS ONE 10(9): e0137826. doi:10.1371/journal.pone.0137826
Abstract: Retinal ganglion cell degeneration underlies the pathophysiology of diseases affecting the retina and optic nerve. Several studies have previously evidenced the anti-apoptotic properties of the bile constituent, tauroursodeoxycholic acid, in diverse models of photoreceptor degeneration. The aim of this study was to investigate the effects of systemic administration of tauroursodeoxycholic acid on N-methyl-D-aspartate (NMDA)-induced damage in the rat retina using a functional and morphological approach. Tauroursodeoxycholic acid was administered intraperitoneally before and after intravitreal injection of NMDA. Three days after insult, full-field electroretinograms showed reductions in the amplitudes of the positive and negative-scotopic threshold responses, scotopic a- and b-waves and oscillatory potentials. Quantitative morphological evaluation of whole-mount retinas demonstrated a reduction in the density of retinal ganglion cells. Systemic administration of tauroursodeoxycholic acid attenuated the functional impairment induced by NMDA, which correlated with a higher retinal ganglion cell density. Our findings sustain the efficacy of tauroursodeoxycholic acid administration in vivo, suggesting it would be a good candidate for the pharmacological treatment of degenerative diseases coursing with retinal ganglion cell loss.
Sponsor: This work was supported by project grants from Spanish Ministerio de Economía y Competitividad-FEDER (http://www.mineco.gob.es) #BFU2012‐36845, Instituto de Salud Carlos III RETICS (http://www.oftared.com) #RD12/0034/0010 and Organización Nacional de Ciegos Españoles (http://www.once.es) to NC; Ministerio de Ciencia e Innovación #JCI‐2009‐05224 to VGV; Universidad de Alicante (http://www.ua.es) #2010-48536273 to GE; Instituto de Salud Carlos III (http://www.isciii.es) #PI13/02098 and RETICS #RD12/0034/0006 to PdV; and FUNDALUCE.
URI: http://hdl.handle.net/10045/49588
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0137826
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2015 Gómez-Vicente et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Peer Review: si
Publisher version: http://dx.doi.org/10.1371/journal.pone.0137826
Appears in Collections:INV - NEUROVIS - Artículos de Revistas

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